PDB: 435 resultsInfo pagesStatus searchChemie searchBIRD

---

1LPH	LYS(B28)PRO(B29)-HUMAN INSULIN Descriptor: CHLORIDE ION, INSULIN, PHENOL, ... Authors: Ciszak, E, Beals, J.M, Frank, B.H, Baker, J.C, Carter, N.D, Smith, G.D. Deposit date: 1995-04-19 Release date: 1996-06-20 Last modified: 2021-11-03 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Role of C-terminal B-chain residues in insulin assembly: the structure of hexameric LysB28ProB29-human insulin. Structure, 3, 1995
2R35	Crystal structure of RB human arg-insulin Descriptor: Insulin, RUBIDIUM ION, SODIUM ION Authors: Sreekanth, R, Pattabhi, V, Rajan, S.S. Deposit date: 2007-08-29 Release date: 2008-09-02 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Metal induced structural changes observed in hexameric insulin Int.J.Biol.Macromol., 44, 2009
7ELJ	Prion Derived Tetrapeptide Stabilizes Thermolabile Insulin via Conformational Trapping Descriptor: IS1, Insulin A Chain, Insulin B chain Authors: Banerjee, N. Deposit date: 2021-04-11 Release date: 2021-04-28 Last modified: 2021-07-07 Method: SOLUTION NMR Cite: Prion-derived tetrapeptide stabilizes thermolabile insulin via conformational trapping. Iscience, 24, 2021
3KR3	Crystal structure of IGF-II antibody complex Descriptor: 1,2-ETHANEDIOL, Insulin-like growth factor II, antibody-Fab (heavy chain), ... Authors: Peat, T.S, Newman, J, Adams, T.E. Deposit date: 2009-11-17 Release date: 2010-06-16 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo. Mol.Cancer Ther., 9, 2010
3KQ6	Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ... Authors: Wan, Z.L, Hu, S.Q, Whittaker, L, Phillips, N.B, Whittake, J, Ismail-Beigi, F, Weiss, M.A. Deposit date: 2009-11-17 Release date: 2010-02-23 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot. J.Biol.Chem., 285, 2010
6X4X	B24Y DKP insulin Descriptor: Insulin, Insulin chain A Authors: Weiss, M.A, Yang, Y. Deposit date: 2020-05-24 Release date: 2020-08-05 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Evolution of insulin at the edge of foldability and its medical implications. Proc.Natl.Acad.Sci.USA, 117, 2020
8ONK	Human insulin in complex with the analytical antibody S1 Fab and the analytical antibody HUI-001 Fab Descriptor: Heavy chain of analytical antibody HUI-001 Fab, Heavy chain of analytical antibody S1 Fab, Insulin A chain, ... Authors: Johansson, E. Deposit date: 2023-04-03 Release date: 2024-04-10 Method: X-RAY DIFFRACTION (3.403 Å) Cite: Macromolecular structure of insulin and IgE clonality impacts IgE-mediated activation of sensitized basophils To Be Published
8ONI	Human insulin in complex with the analytical antibody S1 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of analytical antibody S1 Fab, Insulin A chain, ... Authors: Johansson, E. Deposit date: 2023-04-03 Release date: 2024-04-10 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Macromolecular structure of insulin and IgE clonality impacts IgE-mediated activation of sensitized basophils To Be Published
3LRI	Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I Descriptor: PROTEIN (INSULIN-LIKE GROWTH FACTOR I) Authors: Laajoki, L.G, Francis, G.L, Wallace, J.C, Carver, J.A, Keniry, M.A. Deposit date: 1999-04-13 Release date: 2000-05-23 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I J.Biol.Chem., 275, 2000
4XC4	Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide Descriptor: CHLORIDE ION, Insulin, SODIUM ION, ... Authors: Bracey, A.W, Magis, A.T, Buschard, K, Osterbye, T, Bailey, K.M, Ostrov, D.A. Deposit date: 2014-12-17 Release date: 2015-02-11 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.499 Å) Cite: Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide To Be Published
6Z7Y	Human insulin in complex with the analytical antibody OXI-005 Fab Descriptor: Insulin, OXI-005 Fab Heavy chain, OXI-005 Fab Light chain Authors: Johansson, E. Deposit date: 2020-06-02 Release date: 2020-12-30 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Insulin binding to the analytical antibody sandwich pair OXI-005 and HUI-018: Epitope mapping and binding properties. Protein Sci., 30, 2021
3MTH	X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Descriptor: 4-HYDROXY-BENZOIC ACID METHYL ESTER, CHLORIDE ION, METHYLPARABEN INSULIN, ... Authors: Whittingham, J.L, Dodson, E.J, Moody, P.C.E, Dodson, G.G. Deposit date: 1995-09-13 Release date: 1996-01-29 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents, thiocyanate, methylparaben, and phenol. Biochemistry, 34, 1995
4RXW	Crystal Structure of the cobalt human insulin derivative Descriptor: COBALT (II) ION, Insulin A chain, Insulin B chain Authors: Prugovecki, B, Ivetic, N, Matkovic-Calogovic, D. Deposit date: 2014-12-12 Release date: 2015-01-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Crystal Structure of the cobalt human insulin derivative TO BE PUBLISHED
4P65	Crystal structure of an cyclohexylalanine substituted insulin analog. Descriptor: CHLORIDE ION, Insulin, PHENOL, ... Authors: Pandyarajan, V, Wan, Z, Weiss, M.A. Deposit date: 2014-03-21 Release date: 2014-10-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Aromatic Anchor at an Invariant Hormone-Receptor Interface: FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN. J.Biol.Chem., 289, 2014
4UNE	Human insulin B26Phe mutant crystal structure Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION Authors: Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. Deposit date: 2014-05-28 Release date: 2014-10-15 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex Acta Crystallogr.,Sect.D, 70, 2014
4UNG	Human insulin B26Asn mutant crystal structure Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION Authors: Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. Deposit date: 2014-05-28 Release date: 2014-10-15 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex Acta Crystallogr.,Sect.D, 70, 2014
7NHU	Crystal structure of desB30 insulin produced by cell free protein synthesis Descriptor: Insulin Authors: Johansson, E. Deposit date: 2021-02-11 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Cell free protein synthesis versus yeast expression - A comparison using insulin as a model protein. Protein Expr.Purif., 186, 2021
4UNH	Human insulin B26Gly mutant crystal structure Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION Authors: Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. Deposit date: 2014-05-28 Release date: 2014-10-15 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex Acta Crystallogr.,Sect.D, 70, 2014
7JP3	Des-B29,B30-insulin Descriptor: CHLORIDE ION, Insulin B chain,Insulin A chain, PHENOL, ... Authors: Yoder, J, Weiss, M.A, DiMarchi, R, Zaykov, A. Deposit date: 2020-08-07 Release date: 2021-10-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Des-B29,B30-insulin To Be Published
7INS	STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z Descriptor: GENERAL PROTAMINE CHAIN, INSULIN (CHAIN A), INSULIN (CHAIN B), ... Authors: Balschmidt, P, Hansen, F.B, Dodson, E, Dodson, G, Korber, F. Deposit date: 1991-09-03 Release date: 1994-01-31 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of porcine insulin cocrystallized with clupeine Z. Acta Crystallogr.,Sect.B, 47, 1991
5WBT	Solution Structure and Dynamics of an Ultra-Stable Single-Chain Insulin Analog STUDIES OF AN ENGINEERED MONOMER AND IMPLICATIONS FOR RECEPTOR BINDING Descriptor: Insulin Authors: Glidden, M.D, Yang, Y, Wickramasinghe, N.P, Weiss, M.A. Deposit date: 2017-06-29 Release date: 2017-11-15 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding. J. Biol. Chem., 293, 2018
5WDM	An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein Descriptor: Single-chain insulin analog Authors: Yee, V.C, Aldabbagh, K, Peng, Y. Deposit date: 2017-07-05 Release date: 2017-11-15 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.803 Å) Cite: An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein. J. Biol. Chem., 293, 2018
7Z5L	Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and dimethyl sulfoxide (DMSO) Descriptor: GLYCEROL, Insulin A chain, Insulin B chain, ... Authors: van den Elsen, J.M.H, Wahid, A.A, Crennell, C. Deposit date: 2022-03-09 Release date: 2023-03-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling To Be Published
7Z5Q	Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and p-Hydroxyphenylpyruvate (HPP) Descriptor: Insulin, Insulin A chain, SULFATE ION Authors: van den Elsen, J.M.H, Wahid, A.A, Crennell, S.J. Deposit date: 2022-03-09 Release date: 2023-03-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling To Be Published
5VIZ	X-Ray structure of Insulin Glargine Descriptor: Insulin, chain alpha, chain beta Authors: Reyes-Grajeda, J.P, Romero, A. Deposit date: 2017-04-17 Release date: 2017-10-18 Method: X-RAY DIFFRACTION (1.7 Å) Cite: X-Ray structure of Insulin Glargine To Be Published

 

12345678910111213141516>