PDB: 141 件ウェブページステータス検索Chemie searchBIRD

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7ZJF	R399E, a mutated form of GDF5, for disease modification of osteoarthritis 分子名称: Growth/differentiation factor 5 著者 Gigout, A, Wekmann, D, Menges, S, Brenneis, C, Henson, F, Cowan, K.J, Musil, D, Thudium, C, Guehring, H, Michaelis, M, Kleinschmidt-Doerr, K. 登録日 2022-04-10 公開日 2022-09-28 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 R399E, A Mutated Form of Growth and Differentiation Factor 5, for Disease Modification of Osteoarthritis. Arthritis Rheumatol, 75, 2023
7PPA	High resolution structure of bone morphogenetic protein receptor type II (BMPRII) extracellular domain in complex with BMP10 分子名称: Bone morphogenetic protein 10, Bone morphogenetic protein receptor type-2, GLYCEROL 著者 Guo, J, Yu, M, Read, R.J, Li, W. 登録日 2021-09-13 公開日 2022-05-11 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun, 13, 2022
5E4G	Crystal structure of human growth differentiation factor 11 (GDF-11) 分子名称: Growth/differentiation factor 11, TETRAETHYLENE GLYCOL 著者 Padyana, A.K, Vaidialingam, B, Hayes, D.B, Gupta, P, Franti, M, Farrow, N.A. 登録日 2015-10-06 公開日 2016-03-09 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal structure of human GDF11. Acta Crystallogr.,Sect.F, 72, 2016
2ASK	Structure of human Artemin 分子名称: SULFATE ION, artemin 著者 Silvian, L, Jin, P, Carmillo, P, Boriack-Sjodin, P.A, Pelletier, C, Rushe, M, Gong, B.J, Sah, D, Pepinsky, B, Rossomando, A. 登録日 2005-08-23 公開日 2006-06-13 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Artemin crystal structure reveals insights into heparan sulfate binding. Biochemistry, 45, 2006
5NMZ	human Neurturin (97-197) 分子名称: GLYCEROL, Neurturin 著者 Bigalke, J.M, Sandmark, J, Roth, R. 登録日 2017-04-07 公開日 2018-02-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling. J. Biol. Chem., 293, 2018
6Z3J	Repulsive Guidance Molecule B (RGMB) in complex with Growth Differentiation Factor 5 (GDF5) (crystal form 1) 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... 著者 Malinauskas, T, Peer, T.V, Bishop, B, Muller, T.D, Siebold, C. 登録日 2020-05-20 公開日 2020-07-01 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex. Proc.Natl.Acad.Sci.USA, 117, 2020
2GYZ	Crystal structure of human artemin 分子名称: neurotrophic factor artemin isoform 3 著者 Wang, X.Q, Garcia, K.C. 登録日 2006-05-10 公開日 2006-06-27 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors. Structure, 14, 2006
5F3B	Structure of myostatin in complex with chimeric RK35 antibody 分子名称: GLYCEROL, Growth/differentiation factor 8, RK35 Chimeric antibody heavy chain, ... 著者 Parris, K.D, Mosyak, L. 登録日 2015-12-02 公開日 2016-09-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody. Mabs, 8, 2016
2TGI	CRYSTAL STRUCTURE OF TRANSFORMING GROWTH FACTOR-BETA2: AN UNUSUAL FOLD FOR THE SUPERFAMILY 分子名称: TRANSFORMING GROWTH FACTOR ,BETA 2 著者 Daopin, S, Davies, D.R. 登録日 1993-10-20 公開日 1994-01-31 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of transforming growth factor-beta 2: an unusual fold for the superfamily. Science, 257, 1992
5TX2	Miniature TGF-beta2 3-mutant monomer 分子名称: Transforming growth factor beta-2 著者 Taylor, A.B, Kim, S.K, Hart, P.J, Hinck, A.P. 登録日 2016-11-15 公開日 2017-03-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 An engineered transforming growth factor beta (TGF-beta ) monomer that functions as a dominant negative to block TGF-beta signaling. J. Biol. Chem., 292, 2017
2H62	Crystal structure of a ternary ligand-receptor complex of BMP-2 分子名称: Acvr2b protein, Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA 著者 Mueller, T.D. 登録日 2006-05-30 公開日 2007-04-10 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor. Bmc Struct.Biol., 7, 2007
1REW	Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor 分子名称: bone morphogenetic protein 2, bone morphogenetic protein receptor type IA 著者 Keller, S, Nickel, J, Zhang, J.-L, Sebald, W, Mueller, T.D. 登録日 2003-11-07 公開日 2004-05-04 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.863 Å) 主引用文献 Molecular recognition of BMP-2 and BMP receptor IA. Nat.Struct.Mol.Biol., 11, 2004
5I05	Crystal structure of human BMP9 at 1.87 A resolution 分子名称: GLYCEROL, Growth/differentiation factor 2 著者 Saito, T, Bokhove, M, Jovine, L. 登録日 2016-02-03 公開日 2017-06-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1. Cell Rep, 19, 2017
5TX4	Derivative of mouse TGF-beta2, with a deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S, L89V, I92V, K94R T95K, I98V single amino acid substitutions, bound to human TGF-beta type II receptor ectodomain residues 15-130 分子名称: TGF-beta receptor type-2, Transforming growth factor beta-2 著者 Hinck, A.P, Kim, S. 登録日 2016-11-15 公開日 2017-03-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.876 Å) 主引用文献 An engineered transforming growth factor beta (TGF-beta ) monomer that functions as a dominant negative to block TGF-beta signaling. J. Biol. Chem., 292, 2017
1AGQ	GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT 分子名称: GLIAL CELL-DERIVED NEUROTROPHIC FACTOR 著者 Eigenbrot, C, Gerber, N. 登録日 1997-03-25 公開日 1997-06-05 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding. Nat.Struct.Biol., 4, 1997
4MPL	Crystal structure of BMP9 at 1.90 Angstrom 分子名称: Growth/differentiation factor 2 著者 Li, W, Morrell, N.W, Wei, Z. 登録日 2013-09-13 公開日 2014-09-17 最終更新日 2021-06-02 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Regulation of Bone Morphogenetic Protein 9 (BMP9) by Redox-dependent Proteolysis. J.Biol.Chem., 289, 2014
5UHM	Apo-Structure of Mature Growth Differentiation Factor 11 分子名称: Growth/differentiation factor 11 著者 Goebel, E, Thompson, T. 登録日 2017-01-11 公開日 2017-03-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for potency differences between GDF8 and GDF11. BMC Biol., 15, 2017
6XM2	The structure of the 4A11.v7 antibody in complex with human TGFb2 分子名称: 4A11.v7 heavy chain Fab (VH-CH1) IgG1 humanized, 4A11.v7 kappa light chain Fab (VL-CL) humanized, Transforming growth factor beta-2 著者 Lupardus, P.J, Yin, J.P. 登録日 2020-06-29 公開日 2021-07-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 TGF beta 2 and TGF beta 3 isoforms drive fibrotic disease pathogenesis. Sci Transl Med, 13, 2021
4N1D	Nodal/BMP2 chimera NB250 分子名称: Nodal/BMP2 chimera protein 著者 Esquivies, L. 登録日 2013-10-04 公開日 2013-12-04 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (1.912 Å) 主引用文献 Designer Nodal/BMP2 Chimeras Mimic Nodal Signaling, Promote Chondrogenesis, and Reveal a BMP2-like Structure. J.Biol.Chem., 289, 2014
2GH0	Growth factor/receptor complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GDNF family receptor alpha-3, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Wang, X.Q. 登録日 2006-03-24 公開日 2006-06-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors. Structure, 14, 2006
2H64	Crystal structure of a ternary ligand-receptor complex of BMP-2 分子名称: Acvr2b protein, Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA 著者 Mueller, T.D, Sebald, W, Weber, D. 登録日 2006-05-30 公開日 2007-04-10 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor. Bmc Struct.Biol., 7, 2007
8DC0	Rat Betaglycan Zona Pellucida Domain (ZPC) in complex with mini monomer TGFb2 (mmTGF-b2-7M2R) 分子名称: Transforming growth factor beta receptor type 3, Transforming growth factor beta-2 著者 Wieteska, L, Taylor, A.B, Hinck, A.P. 登録日 2022-06-15 公開日 2023-06-21 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Rat Betaglycan Zona Pellucida Domain (ZPC) in complex with mini monomer TGFb2 (mmTGF-b2-7M2R) To Be Published
1TFG	AN UNUSUAL FEATURE REVEALED BY THE CRYSTAL STRUCTURE AT 2.2 ANGSTROMS RESOLUTION OF HUMAN TRANSFORMING GROWTH FACTOR-BETA2 分子名称: TRANSFORMING GROWTH FACTOR, BETA 2 著者 Gruetter, M, Schlunegger, M. 登録日 1992-11-17 公開日 1993-10-31 最終更新日 2019-08-14 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 An unusual feature revealed by the crystal structure at 2.2 A resolution of human transforming growth factor-beta 2. Nature, 358, 1992
5VZ3	Growth Factor Crystal Structure at 1.97 Angstrom Resolution 分子名称: Growth/differentiation factor 15 著者 Lakshminarasimhan, D, White, A, Suto, R.K. 登録日 2017-05-26 公開日 2017-09-27 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15. Nature, 550, 2017
6I9J	Human transforming growth factor beta2 in a tetragonal crystal form 分子名称: Transforming growth factor beta-2 proprotein 著者 Gomis-Ruth, F.X, Marino-Puertas, L, del Amo-Maestro, L, Goulas, T. 登録日 2018-11-23 公開日 2019-07-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor beta 2 in a new conformation. Sci Rep, 9, 2019

 

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