5TX4
Derivative of mouse TGF-beta2, with a deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S, L89V, I92V, K94R T95K, I98V single amino acid substitutions, bound to human TGF-beta type II receptor ectodomain residues 15-130
Summary for 5TX4
| Entry DOI | 10.2210/pdb5tx4/pdb |
| Related | 5TX2 5TX6 |
| Descriptor | TGF-beta receptor type-2, Transforming growth factor beta-2 (3 entities in total) |
| Functional Keywords | tgf-beta, tgf-beta type ii receptor, transferase-cytokine complex, transferase/cytokine |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 23726.23 |
| Authors | Hinck, A.P.,Kim, S. (deposition date: 2016-11-15, release date: 2017-03-01, Last modification date: 2023-10-04) |
| Primary citation | Kim, S.K.,Barron, L.,Hinck, C.S.,Petrunak, E.M.,Cano, K.E.,Thangirala, A.,Iskra, B.,Brothers, M.,Vonberg, M.,Leal, B.,Richter, B.,Kodali, R.,Taylor, A.B.,Du, S.,Barnes, C.O.,Sulea, T.,Calero, G.,Hart, P.J.,Hart, M.J.,Demeler, B.,Hinck, A.P. An engineered transforming growth factor beta (TGF-beta ) monomer that functions as a dominant negative to block TGF-beta signaling. J. Biol. Chem., 292:7173-7188, 2017 Cited by PubMed: 28228478DOI: 10.1074/jbc.M116.768754 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.876 Å) |
Structure validation
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