5TX4

Derivative of mouse TGF-beta2, with a deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S, L89V, I92V, K94R T95K, I98V single amino acid substitutions, bound to human TGF-beta type II receptor ectodomain residues 15-130

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	TGF-beta receptor type-2	polymer	116	13225.0	1	UniProt (P37173) Pfam (PF08917) In PDB	Homo sapiens (Human)	TGFR-2,TGF-beta type II receptor,Transforming growth factor-beta receptor type II,TbetaR-II
2	B	Transforming growth factor beta-2	polymer	92	10501.2	1	UniProt (P61812) Pfam (PF00019) In PDB	Homo sapiens (Human)	TGF-beta-2,BSC-1 cell growth inhibitor,Cetermin,Glioblastoma-derived T-cell suppressor factor,G-TSF,Polyergin
3		water	water		18.0	82	Chemie (HOH)

Sequence modifications

B: 1 - 92 (UniProt: P61812)

PDB	External Database	Details
Arg 25	Lys 327	engineered mutation
Lys 26	Arg 328	engineered mutation
-	Leu 353	deletion
-	Trp 354	deletion
-	Ser 355	deletion
-	Ser 356	deletion
-	Asp 357	deletion
-	Thr 358	deletion
-	Gln 359	deletion
-	His 360	deletion
-	Ser 361	deletion
-	Arg 362	deletion
-	Val 363	deletion
-	Leu 364	deletion
-	Ser 365	deletion
-	Leu 366	deletion
-	Tyr 367	deletion
-	Asn 368	deletion
-	Thr 369	deletion
-	Ile 370	deletion
-	Asn 371	deletion
-	Pro 372	deletion
Arg 51	Glu 373	engineered mutation
Lys 54	Ala 376	engineered mutation
Ser 57	Cys 379	engineered mutation
Val 69	Leu 391	engineered mutation
Val 72	Ile 394	engineered mutation
Arg 74	Lys 396	engineered mutation
Lys 75	Thr 397	engineered mutation
Val 78	Ile 400	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	23726.2
All*	Total formula weight	23726.2

*Water molecules are not included.