5TX4
Derivative of mouse TGF-beta2, with a deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S, L89V, I92V, K94R T95K, I98V single amino acid substitutions, bound to human TGF-beta type II receptor ectodomain residues 15-130
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TGF-beta receptor type-2 | polymer | 116 | 13225.0 | 1 | UniProt (P37173) Pfam (PF08917) | Homo sapiens (Human) | TGFR-2,TGF-beta type II receptor,Transforming growth factor-beta receptor type II,TbetaR-II |
| 2 | B (B) | Transforming growth factor beta-2 | polymer | 92 | 10501.2 | 1 | UniProt (P61812) Pfam (PF00019) | Homo sapiens (Human) | TGF-beta-2,BSC-1 cell growth inhibitor,Cetermin,Glioblastoma-derived T-cell suppressor factor,G-TSF,Polyergin |
| 3 | C, D (A, B) | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
B: 1 - 92 (UniProt: P61812)
| PDB | External Database | Details |
|---|---|---|
| Arg 25 | Lys 327 | engineered mutation |
| Lys 26 | Arg 328 | engineered mutation |
| - | Leu 353 | deletion |
| - | Trp 354 | deletion |
| - | Ser 355 | deletion |
| - | Ser 356 | deletion |
| - | Asp 357 | deletion |
| - | Thr 358 | deletion |
| - | Gln 359 | deletion |
| - | His 360 | deletion |
| - | Ser 361 | deletion |
| - | Arg 362 | deletion |
| - | Val 363 | deletion |
| - | Leu 364 | deletion |
| - | Ser 365 | deletion |
| - | Leu 366 | deletion |
| - | Tyr 367 | deletion |
| - | Asn 368 | deletion |
| - | Thr 369 | deletion |
| - | Ile 370 | deletion |
| - | Asn 371 | deletion |
| - | Pro 372 | deletion |
| Arg 51 | Glu 373 | engineered mutation |
| Lys 54 | Ala 376 | engineered mutation |
| Ser 57 | Cys 379 | engineered mutation |
| Val 69 | Leu 391 | engineered mutation |
| Val 72 | Ile 394 | engineered mutation |
| Arg 74 | Lys 396 | engineered mutation |
| Lys 75 | Thr 397 | engineered mutation |
| Val 78 | Ile 400 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 23726.2 | |
| All* | Total formula weight | 23726.2 |
