PDB: 522 件ウェブページステータス検索Chemie searchBIRD

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2PZ1	Crystal Structure of Auto-inhibited Asef 分子名称: Rho guanine nucleotide exchange factor 4 著者 Betts, L, Sondek, J, Rossman, K.L. 登録日 2007-05-17 公開日 2007-08-21 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression. Nat.Struct.Mol.Biol., 14, 2007
6PBC	Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, SODIUM ION 著者 Hajicek, N, Sondek, J. 登録日 2019-06-13 公開日 2020-01-08 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.46 Å) 主引用文献 Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations. Elife, 8, 2019
8GMB	Crystal structure of the full-length Bruton's tyrosine kinase (PH-TH domain not visible) 分子名称: 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, Tyrosine-protein kinase BTK 著者 Lin, D.Y, Andreotti, A.H. 登録日 2023-03-24 公開日 2023-08-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12, 2024
6F3F	Autoinhibited Src kinase bound to ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Tyrosine-protein kinase 著者 von Raussendorf, F, Leonard, T.A. 登録日 2017-11-28 公開日 2017-12-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.41795778 Å) 主引用文献 A switch in nucleotide affinity governs activation of the Src and Tec family kinases. Sci Rep, 7, 2017
8SSN	Abl kinase in complex with SKI and asciminib 分子名称: 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Ludewig, H, Kim, C, Kern, D. 登録日 2023-05-08 公開日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 A biophysical framework for double-drugging kinases. Proc.Natl.Acad.Sci.USA, 120, 2023
7Z3J	Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate 分子名称: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... 著者 Pinotsis, N, Bunney, T.D, Katan, M. 登録日 2022-03-02 公開日 2022-07-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Characterization of the membrane interactions of phospholipase C gamma reveals key features of the active enzyme. Sci Adv, 8, 2022
8XN8	The Crystal Structure of SRC from Biortus. 分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... 著者 Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C. 登録日 2023-12-29 公開日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The Crystal Structure of SRC from Biortus. To Be Published
7YQE	Structure of human SRC regulatory domains in complex with the C-terminal PRRP motifs of GPR54. 分子名称: Proto-oncogene tyrosine-protein kinase Src,KiSS-1 receptor 著者 Song, G, Xu, S. 登録日 2022-08-06 公開日 2023-08-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src. Nat Commun, 15, 2024
4XI2	Crystal Structure of an auto-inhibited form of Bruton's Tryrosine Kinase 分子名称: GOLD ION, Tyrosine-protein kinase BTK 著者 Vogan, E.M, Harrison, S.C. 登録日 2015-01-06 公開日 2015-02-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate. Elife, 4, 2015
5MO4	ABL1 kinase (T334I_D382N) in complex with asciminib and nilotinib 分子名称: Nilotinib, Tyrosine-protein kinase ABL1, asciminib 著者 Cowan-Jacob, S.W. 登録日 2016-12-13 公開日 2017-04-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1. Nature, 543, 2017
8DGQ	Crystal structure of p120RasGAP SH2-SH3-SH2 in complex with p190RhoGAP doubly phosphorylated peptide 分子名称: MALONATE ION, Ras GTPase-activating protein 1, Rho GTPase-activating protein 35 著者 Stiegler, A.L, Vish, K.J, Boggon, T.J. 登録日 2022-06-24 公開日 2022-11-02 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Tandem engagement of phosphotyrosines by the dual SH2 domains of p120RasGAP. Structure, 30, 2022
7UY0	Crystal structure of human Fgr tyrosine kinase in complex with A-419259 分子名称: 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CHLORIDE ION, GLYCEROL, ... 著者 Du, S, Alvarado, J.J, Smithgall, T.E. 登録日 2022-05-06 公開日 2022-12-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr. Structure, 30, 2022
7UY3	Crystal structure of human Fgr tyrosine kinase in complex with TL02-59 分子名称: 1,2-ETHANEDIOL, 3-[(6,7-dimethoxyquinazolin-4-yl)oxy]-N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methylbenzamide, GLYCEROL, ... 著者 Du, S, Alvarado, J.J, Smithgall, T.E. 登録日 2022-05-06 公開日 2022-12-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr. Structure, 30, 2022
8DGO	Growth Factor Receptor-Bound Protein 2 (Grb2) bound to phosphorylated PEAK3 (pY24) peptide 分子名称: Growth factor receptor bound protein 2, Phosphorylated PEAK3 (pY24) peptide 著者 Roy, M.J, Hardy, J.M, Lucet, I.S. 登録日 2022-06-24 公開日 2023-06-07 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling. Nat Commun, 14, 2023
3NHN	Crystal structure of the SRC-family kinase HCK SH3-SH2-linker regulatory region 分子名称: Tyrosine-protein kinase HCK 著者 Alvarado, J.J, Betts, L, Moroco, J.A, Smithgall, T.E, Yeh, J.I. 登録日 2010-06-14 公開日 2010-09-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism. J.Biol.Chem., 285, 2010
6AMW	Abl1b Regulatory Module 'Activating' conformation 分子名称: Tyrosine-protein kinase ABL1 著者 Kalodimos, C.G, Rossi, P, Saleh, T. 登録日 2017-08-11 公開日 2017-09-27 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Atomic view of the energy landscape in the allosteric regulation of Abl kinase. Nat. Struct. Mol. Biol., 24, 2017
6AMV	Abl 1b Regulatory Module 'inhibiting state' 分子名称: Tyrosine-protein kinase ABL1 著者 Kalodimos, C.G, Saleh, T, Rossi, P. 登録日 2017-08-11 公開日 2017-09-27 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Atomic view of the energy landscape in the allosteric regulation of Abl kinase. Nat. Struct. Mol. Biol., 24, 2017
3VS2	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 分子名称: 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Tomabechi, Y, Niwa, H, Parker, J.L, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.609 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VRY	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane 分子名称: 4-Amino-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Tomabechi, Y, Niwa, H, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.481 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS7	Crystal structure of HCK complexed with a pyrazolo-pyrimidine inhibitor 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 分子名称: 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Honda, K, Niwa, H, Toyama, M, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (3.001 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VRZ	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea 分子名称: 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Tomabechi, Y, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.218 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS1	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea 分子名称: 1-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Tomabechi, Y, Toyama, M, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.464 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS4	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 5-(4-phenoxyphenyl)-7-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 分子名称: 5-(4-phenoxyphenyl)-7-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Tomabechi, Y, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.747 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS0	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide 分子名称: CALCIUM ION, CHLORIDE ION, N-[4-(4-amino-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide, ... 著者 Kuratani, M, Honda, K, Tomabechi, Y, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.934 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013
3VS3	Crystal structure of HCK complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 分子名称: 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, CALCIUM ION, CHLORIDE ION, ... 著者 Kuratani, M, Tomaebchi, Y, Handa, N, Yokoyama, S. 登録日 2012-04-21 公開日 2013-05-01 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo Sci Transl Med, 5, 2013

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