PDB: 593 件ウェブページステータス検索Chemie searchBIRD

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1FU5	NMR STRUCTURE OF THE N-SH2 DOMAIN OF THE P85 SUBUNIT OF PI3-KINASE COMPLEXED TO A DOUBLY PHOSPHORYLATED PEPTIDE DERIVED FROM POLYOMAVIRUS MIDDLE T ANTIGEN 分子名称: DOUBLY PHOSPHORYLATED MIDDLE T ANTIGEN, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT 著者 Weber, T, Schaffhausen, B, Liu, Y, Guenther, U.L. 登録日 2000-09-14 公開日 2001-02-21 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site. Biochemistry, 39, 2000
1H9O	PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, CRYSTAL STRUCTURE AT 1.79 A 分子名称: BETA-PLATELET-DERIVED GROWTH FACTOR RECEPTOR, PHOSPHATIDYLINOSITOL 3-KINASE 著者 Pauptit, R.A, Rowsell, S, Breeze, A.L, Murshudov, G.N, Dennis, C.A, Derbyshire, D.J, Weston, S.A. 登録日 2001-03-14 公開日 2001-03-19 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 NMR Trial Models: Experiences with the Colicin Immunity Protein Im7 and the P85Alpha C-Terminal Sh2-Peptide Complex Acta Crystallogr.,Sect.D, 57, 2001
1G83	CRYSTAL STRUCTURE OF FYN SH3-SH2 分子名称: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE FYN 著者 Arold, S.T, Ulmer, T.S, Mulhern, T.D, Werner, J.M, Ladbury, J.E, Campbell, I.D, Noble, M.E.M. 登録日 2000-11-16 公開日 2001-05-30 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases. J.Biol.Chem., 276, 2001
1JWO	Crystal Structure Analysis of the SH2 Domain of the Csk Homologous Kinase CHK 分子名称: Csk Homologous Kinase 著者 Murthy, T.V.S, Webster, G.D. 登録日 2001-09-04 公開日 2001-09-12 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Recognition of the HER-2/neu Receptor by the SH2 Domain of the Csk Homologous Kinase To be Published
1KA7	SAP/SH2D1A bound to peptide n-Y-c 分子名称: SH2 DOMAIN PROTEIN 1A, peptide n-Y-c 著者 Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. 登録日 2001-10-31 公開日 2001-11-07 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J., 21, 2002
1KA6	SAP/SH2D1A bound to peptide n-pY 分子名称: SH2 DOMAIN PROTEIN 1A, peptide n-pY 著者 Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. 登録日 2001-10-31 公開日 2001-11-07 最終更新日 2021-10-27 実験手法 SOLUTION NMR 主引用文献 A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J., 21, 2002
1IS0	Crystal Structure of a Complex of the Src SH2 Domain with Conformationally Constrained Peptide Inhibitor 分子名称: AY0 GLU GLU ILE peptide, Tyrosine-protein kinase transforming protein SRC 著者 Davidson, J.P, Lubman, O, Rose, T, Waksman, G, Martin, S.F. 登録日 2001-11-02 公開日 2002-02-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide inhibitors of Src SH2 domain binding. J.Am.Chem.Soc., 124, 2002
1KSW	Structure of Human c-Src Tyrosine Kinase (Thr338Gly Mutant) in Complex with N6-benzyl ADP 分子名称: N6-BENZYL ADENOSINE-5'-DIPHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 著者 Witucki, L.A, Huang, X, Shah, K, Liu, Y, Kyin, S, Eck, M.J, Shokat, K.M. 登録日 2002-01-14 公開日 2002-02-27 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Chem.Biol., 9, 2002
1JYR	Xray Structure of Grb2 SH2 Domain Complexed with a Phosphorylated Peptide 分子名称: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, peptide: PSpYVNVQN 著者 Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. 登録日 2001-09-13 公開日 2002-03-13 最終更新日 2018-10-10 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1JYU	Xray Structure of Grb2 SH2 Domain 分子名称: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 著者 Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. 登録日 2001-09-13 公開日 2002-03-13 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1JYQ	Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide 分子名称: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, mAZ-pY-(alpha Me)pY-N-NH2 peptide inhibitor 著者 Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. 登録日 2001-09-13 公開日 2002-03-13 最終更新日 2018-04-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1K9A	Crystal structure analysis of full-length carboxyl-terminal Src kinase at 2.5 A resolution 分子名称: Carboxyl-terminal Src kinase 著者 Ogawa, A, Takayama, Y, Nagata, A, Chong, K.T, Takeuchi, S, Sakai, H, Nakagawa, A, Nada, S, Okada, M, Tsukihara, T. 登録日 2001-10-28 公開日 2002-03-20 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of the carboxyl-terminal Src kinase, Csk. J.Biol.Chem., 277, 2002
1KC2	structure of the triple (Lys(beta)D3Ala, Asp(beta)C8Ala, AspCD2Ala) mutant of the Src SH2 domain bound to the PQpYEEIPI peptide 分子名称: COBALT (II) ION, PQpYEEIPI peptide, Src Tyrosine kinase 著者 Lubman, O.Y, Waksman, G. 登録日 2001-11-07 公開日 2002-04-17 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Dissection of the energetic coupling across the Src SH2 domain-tyrosyl phosphopeptide interface. J.Mol.Biol., 316, 2002
1IJR	Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic 分子名称: (4-{2-ACETYLAMINO-2-[1-(3-CARBAMOYL-4-CYCLOHEXYLMETHOXY-PHENYL)-ETHYLCARBAMOYL}-ETHYL}-2-PHOSPHONO-PHENOXY)-ACETIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK 著者 Kawahata, N.H, Yang, M.H, Luke, G.P, Shakespeare, W.C, Sundaramoorthi, R. 登録日 2001-04-27 公開日 2002-05-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain. Bioorg.Med.Chem.Lett., 11, 2001
1JU5	Ternary complex of an Crk SH2 domain, Crk-derived phophopeptide, and Abl SH3 domain by NMR spectroscopy 分子名称: Abl, Crk 著者 Donaldson, L.W, Pawson, T, Kay, L.E, Forman-Kay, J.D. 登録日 2001-08-23 公開日 2002-11-06 最終更新日 2021-11-10 実験手法 SOLUTION NMR 主引用文献 Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide Proc.Natl.Acad.Sci.USA, 99, 2002
1LUK	NMR Structure of the Itk SH2 domain, Pro287cis, Energy minimized average structure 分子名称: Tyrosine-protein kinase ITK/TSK 著者 Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.H. 登録日 2002-05-22 公開日 2002-11-27 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LUN	NMR Structure of the Itk SH2 domain, Pro287trans, energy minimized average structure 分子名称: Tyrosine-protein kinase ITK/TSK 著者 Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. 登録日 2002-05-22 公開日 2002-11-27 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LUI	NMR Structures of Itk SH2 domain, Pro287cis isoform, ensemble of 20 low energy structures 分子名称: Tyrosine-protein kinase ITK/TSK 著者 Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.M. 登録日 2002-05-22 公開日 2002-11-27 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LUM	NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures 分子名称: Tyrosine-protein kinase ITK/TSK 著者 Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. 登録日 2002-05-22 公開日 2002-11-27 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1OO3	P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase 分子名称: Phosphatidylinositol 3-kinase regulatory alpha subunit 著者 Guenther, U.L, Weyrauch, B, Schaffhausen, B. 登録日 2003-03-03 公開日 2003-03-25 最終更新日 2021-11-10 実験手法 SOLUTION NMR 主引用文献 Nuclear magnetic resonance structure of the P395S mutant of the N-SH2 domain of the p85 subunit of PI3 kinase: an SH2 domain with altered specificity Biochemistry, 42, 2003
1OO4	P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase complexed to a peptide derived from PDGFr 分子名称: 8-mer peptide from PDGFr, Phosphatidylinositol 3-kinase regulatory alpha subunit 著者 Guenther, U.L, Weyrauch, B, Schaffhausen, B. 登録日 2003-03-03 公開日 2003-03-25 最終更新日 2023-11-15 実験手法 SOLUTION NMR 主引用文献 Nuclear magnetic resonance structure of the P395S mutant of the N-SH2 domain of the p85 subunit of PI3 kinase: an SH2 domain with altered specificity Biochemistry, 42, 2003
1I3Z	MURINE EAT2 SH2 DOMAIN IN COMPLEX WITH SLAM PHOSPHOPEPTIDE 分子名称: EWS/FLI1 ACTIVATED TRANSCRIPT 2, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE 著者 Lu, J, Poy, F, Morra, M, Terhorst, C, Eck, M.J. 登録日 2001-02-19 公開日 2003-04-08 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. Eur.J.Biochem., 20, 2001
1OPK	Structural basis for the auto-inhibition of c-Abl tyrosine kinase 分子名称: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, GLYCEROL, MYRISTIC ACID, ... 著者 Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J. 登録日 2003-03-06 公開日 2003-04-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell(Cambridge,Mass.), 112, 2003
1OPL	Structural basis for the auto-inhibition of c-Abl tyrosine kinase 分子名称: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, MYRISTIC ACID, proto-oncogene tyrosine-protein kinase 著者 Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J. 登録日 2003-03-06 公開日 2003-04-08 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (3.42 Å) 主引用文献 Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell(Cambridge,Mass.), 112, 2003
1NRV	Crystal structure of the SH2 domain of Grb10 分子名称: Growth factor receptor-bound protein 10 著者 Stein, E.G, Hubbard, S.R. 登録日 2003-01-25 公開日 2003-04-15 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity. J.Biol.Chem., 278, 2003

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