4TRX
 
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3TRX
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2K6D
 | | CIN85 Sh3-C domain in complex with ubiquitin | | Descriptor: | SH3 domain-containing kinase-binding protein 1, Ubiquitin | | Authors: | Forman-Kay, J, Bezsonova, I. | | Deposit date: | 2008-07-07 | | Release date: | 2008-08-19 | | Last modified: | 2018-07-04 | | Method: | SOLUTION NMR | | Cite: | Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination.
Biochemistry, 47, 2008
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2A36
 | | Solution structure of the N-terminal SH3 domain of DRK | | Descriptor: | Protein E(sev)2B | | Authors: | Forman-Kay, J.D, Bezsonova, I, Singer, A, Choy, W.-Y, Tollinger, M. | | Deposit date: | 2005-06-23 | | Release date: | 2005-12-13 | | Last modified: | 2022-03-09 | | Method: | SOLUTION NMR | | Cite: | Structural Comparison of the Unstable drkN SH3 Domain and a Stable Mutant
Biochemistry, 44, 2005
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6UK1
 | | Crystal structure of nucleotide-binding domain 2 (NBD2) of the human Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION | | Authors: | Wang, C, Vorobiev, S.M, Vernon, R.M, Khazanov, N, Senderowitz, H, Forman-Kay, J.D, Hunt, J.F. | | Deposit date: | 2019-10-03 | | Release date: | 2020-10-07 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.693 Å) | | Cite: | A thermodynamically stabilized form of the second nucleotide binding domain from human CFTR shows a catalytically inactive conformation
To Be Published
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3V7D
 | | Crystal Structure of ScSkp1-ScCdc4-pSic1 peptide complex | | Descriptor: | Cell division control protein 4, Protein SIC1, Suppressor of kinetochore protein 1 | | Authors: | Tang, X, Orlicky, S, Mittag, T, Csizmok, V, Pawson, T, Forman-Kay, J, Sicheri, F, Tyers, M. | | Deposit date: | 2011-12-20 | | Release date: | 2012-05-02 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.306 Å) | | Cite: | Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase.
Proc.Natl.Acad.Sci.USA, 109, 2012
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1DDM
 | | SOLUTION STRUCTURE OF THE NUMB PTB DOMAIN COMPLEXED TO A NAK PEPTIDE | | Descriptor: | NUMB ASSOCIATE KINASE, NUMB PROTEIN | | Authors: | Zwahlen, C, Li, S.C, Kay, L.E, Pawson, T, Forman-Kay, J.D. | | Deposit date: | 1999-11-11 | | Release date: | 2000-04-10 | | Last modified: | 2022-02-16 | | Method: | SOLUTION NMR | | Cite: | Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb.
EMBO J., 19, 2000
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2NMB
 | | DNUMB PTB DOMAIN COMPLEXED WITH A PHOSPHOTYROSINE PEPTIDE, NMR, ENSEMBLE OF STRUCTURES. | | Descriptor: | PROTEIN (GPPY PEPTIDE), PROTEIN (NUMB PROTEIN) | | Authors: | Li, S.-C, Zwahlen, C, Vincent, S.J.F, McGlade, C.J, Pawson, T, Forman-Kay, J.D. | | Deposit date: | 1998-10-29 | | Release date: | 1998-11-04 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Structure of a Numb PTB domain-peptide complex suggests a basis for diverse binding specificity.
Nat.Struct.Biol., 5, 1998
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2RPN
 | | A crucial role for high intrinsic specificity in the function of yeast SH3 domains | | Descriptor: | Actin-binding protein, Actin-regulating kinase 1 | | Authors: | Stollar, E.J, Garcia, B, Chong, A, Forman-Kay, J, Davidson, A. | | Deposit date: | 2008-06-12 | | Release date: | 2009-06-16 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | Structural, functional, and bioinformatic studies demonstrate the crucial role of an extended peptide binding site for the SH3 domain of yeast Abp1p
J.Biol.Chem., 284, 2009
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1EZP
 | | GLOBAL FOLD OF MALTODEXTRIN BINDING PROTEIN COMPLEXED WITH BETA-CYCLODEXTRIN USING PEPTIDE ORIENTATIONS FROM DIPOLAR COUPLINGS | | Descriptor: | MALTODEXTRIN BINDING PERIPLASMIC PROTEIN | | Authors: | Mueller, G.A, Choy, W.Y, Yang, D, Forman-Kay, J.D, Venters, R.A, Kay, L.E. | | Deposit date: | 2000-05-11 | | Release date: | 2001-05-08 | | Last modified: | 2021-11-03 | | Method: | SOLUTION NMR | | Cite: | Global folds of proteins with low densities of NOEs using residual dipolar couplings: application to the 370-residue maltodextrin-binding protein.
J.Mol.Biol., 300, 2000
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1EZO
 | | GLOBAL FOLD OF MALTODEXTRIN BINDING PROTEIN COMPLEXED WITH BETA-CYCLODEXTRIN | | Descriptor: | MALTOSE-BINDING PERIPLASMIC PROTEIN | | Authors: | Mueller, G.A, Choy, W.Y, Yang, D, Forman-Kay, J.D, Venters, R.A, Kay, L.E. | | Deposit date: | 2000-05-11 | | Release date: | 2001-05-03 | | Last modified: | 2021-11-03 | | Method: | SOLUTION NMR | | Cite: | Global folds of proteins with low densities of NOEs using residual dipolar couplings: application to the 370-residue maltodextrin-binding protein.
J.Mol.Biol., 300, 2000
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1KA7
 | | SAP/SH2D1A bound to peptide n-Y-c | | Descriptor: | SH2 DOMAIN PROTEIN 1A, peptide n-Y-c | | Authors: | Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. | | Deposit date: | 2001-10-31 | | Release date: | 2001-11-07 | | Last modified: | 2021-10-27 | | Method: | SOLUTION NMR | | Cite: | A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
EMBO J., 21, 2002
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1KA6
 | | SAP/SH2D1A bound to peptide n-pY | | Descriptor: | SH2 DOMAIN PROTEIN 1A, peptide n-pY | | Authors: | Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. | | Deposit date: | 2001-10-31 | | Release date: | 2001-11-07 | | Last modified: | 2021-10-27 | | Method: | SOLUTION NMR | | Cite: | A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
EMBO J., 21, 2002
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2DJY
 | | Solution structure of Smurf2 WW3 domain-Smad7 PY peptide complex | | Descriptor: | Mothers against decapentaplegic homolog 7, Smad ubiquitination regulatory factor 2 | | Authors: | Chong, P.A, Lin, H, Wrana, J.L, Forman-Kay, J.D. | | Deposit date: | 2006-04-06 | | Release date: | 2006-05-02 | | Last modified: | 2022-03-09 | | Method: | SOLUTION NMR | | Cite: | An Expanded WW Domain Recognition Motif Revealed by the Interaction between Smad7 and the E3 Ubiquitin Ligase Smurf2.
J.Biol.Chem., 281, 2006
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2MX4
 | | NMR structure of Phosphorylated 4E-BP2 | | Descriptor: | Eukaryotic translation initiation factor 4E-binding protein 2 | | Authors: | Bah, A, Forman-Kay, J, Vernon, R, Siddiqui, Z, Krzeminski, M, Muhandiram, R, Zhao, C, Sonenberg, N, Kay, L. | | Deposit date: | 2014-12-10 | | Release date: | 2015-01-07 | | Last modified: | 2015-03-18 | | Method: | SOLUTION NMR | | Cite: | Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch.
Nature, 519, 2015
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2AZV
 | | Solution structure of the T22G mutant of N-terminal SH3 domain of DRK (calculated without NOEs) | | Descriptor: | SH2-SH3 adapter protein drk | | Authors: | Bezsonova, I, Singer, A.U, Choy, W.-Y, Tollinger, M, Forman-Kay, J.D. | | Deposit date: | 2005-09-12 | | Release date: | 2005-12-13 | | Last modified: | 2021-10-20 | | Method: | SOLUTION NMR | | Cite: | Structural Comparison of the Unstable drkN SH3 Domain and a Stable Mutant
Biochemistry, 44, 2005
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2AZS
 | | NMR structure of the N-terminal SH3 domain of Drk (calculated without NOE restraints) | | Descriptor: | SH2-SH3 adapter protein drk | | Authors: | Bezsonova, I, Singer, A.U, Choy, W.-Y, Tollinger, M, Forman-Kay, J.D. | | Deposit date: | 2005-09-12 | | Release date: | 2005-12-13 | | Last modified: | 2022-03-09 | | Method: | SOLUTION NMR | | Cite: | Structural Comparison of the Unstable drkN SH3 Domain and a Stable Mutant
Biochemistry, 44, 2005
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1I5H
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2KIS
 | | Solution structure of CA150 FF1 domain and FF1-FF2 interdomain linker | | Descriptor: | Transcription elongation regulator 1 | | Authors: | Murphy, J.M, Hansen, D, Wiesner, S, Muhandiram, D, Borg, M, Smith, M.J, Sicheri, F, Kay, L.E, Forman-Kay, J.D, Pawson, T. | | Deposit date: | 2009-05-08 | | Release date: | 2009-09-08 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays.
J.Mol.Biol., 393, 2009
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2A37
 | | Solution structure of the T22G mutant of N-terminal SH3 domain of DRK (DRKN SH3 DOMAIN) | | Descriptor: | Protein E(sev)2B | | Authors: | Bezsonova, I, Singer, A, Choy, W.-Y, Tollinger, M, Forman-Kay, J.D. | | Deposit date: | 2005-06-23 | | Release date: | 2005-12-13 | | Last modified: | 2021-10-20 | | Method: | SOLUTION NMR | | Cite: | Structural Comparison of the Unstable drkN SH3 Domain and a Stable Mutant
Biochemistry, 44, 2005
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2PLE
 | | NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE | | Descriptor: | PHOSPHOLIPASE C GAMMA-1, C-TERMINAL SH2 DOMAIN, PHOSPHOPEPTIDE FROM PDGF | | Authors: | Pascal, S.M, Singer, A.U, Gish, G, Yamazaki, T, Shoelson, S.E, Pawson, T, Kay, L.E, Forman-Kay, J.D. | | Deposit date: | 1994-08-19 | | Release date: | 1995-01-26 | | Last modified: | 2017-11-29 | | Method: | SOLUTION NMR | | Cite: | Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide.
Cell(Cambridge,Mass.), 77, 1994
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2PLD
 | | NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE | | Descriptor: | PHOSPHOLIPASE C GAMMA-1, C-TERMINAL SH2 DOMAIN, PHOSPHOPEPTIDE FROM PDGF | | Authors: | Pascal, S.M, Singer, A.U, Gish, G, Yamazaki, T, Shoelson, S.E, Pawson, T, Kay, L.E, Forman-Kay, J.D. | | Deposit date: | 1994-08-19 | | Release date: | 1995-01-26 | | Last modified: | 2017-11-29 | | Method: | SOLUTION NMR | | Cite: | Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide.
Cell(Cambridge,Mass.), 77, 1994
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2JQZ
 | | Solution Structure of the C2 domain of human Smurf2 | | Descriptor: | E3 ubiquitin-protein ligase SMURF2 | | Authors: | Wiesner, S, Ogunjimi, A.A, Wang, H, Rotin, D, Sicheri, F, Wrana, J.L, Forman-Kay, J.D. | | Deposit date: | 2007-06-15 | | Release date: | 2007-09-11 | | Last modified: | 2023-12-20 | | Method: | SOLUTION NMR | | Cite: | Autoinhibition of the HECT-Type Ubiquitin Ligase Smurf2 through Its C2 Domain
Cell(Cambridge,Mass.), 130, 2007
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2KXQ
 | | Solution Structure of Smurf2 WW2 and WW3 bound to Smad7 PY motif containing peptide | | Descriptor: | E3 ubiquitin-protein ligase SMURF2, Smad7 PY motif containing peptide | | Authors: | Chong, A, Lin, H, Wrana, J, Forman-Kay, J.D. | | Deposit date: | 2010-05-11 | | Release date: | 2010-10-13 | | Last modified: | 2012-06-20 | | Method: | SOLUTION NMR | | Cite: | Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity.
Proc.Natl.Acad.Sci.USA, 107, 2010
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2LC4
 | | Solution Structure of PilP from Pseudomonas aeruginosa | | Descriptor: | PilP protein | | Authors: | Howell, P, Tammam, S, Chong, P, Forman-Kay, J.D. | | Deposit date: | 2011-04-22 | | Release date: | 2011-12-21 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Characterization of the PilN, PilO and PilP type IVa pilus subcomplex.
Mol.Microbiol., 82, 2011
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