SAP/SH2D1A bound to peptide n-Y-c

Summary for 1KA7

DescriptorSH2 DOMAIN PROTEIN 1A, peptide n-Y-c (2 entities in total)
Functional Keywordssh2 domain, protein-peptide complex, immune system
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm (Probable) O60880
Cell membrane; Single-pass type I membrane protein Q13291
Total number of polymer chains2
Total molecular weight15643.89
Hwang, P.M.,Li, C.,Morra, M.,Lillywhite, J.,Gertler, F.,Terhorst, C.,Kay, L.E.,Pawson, T.,Forman-Kay, J.,Li, S.-C. (deposition date: 2001-10-31, release date: 2001-11-07, Last modification date: 2011-07-13)
Primary citation
Hwang, P.M.,Li, C.,Morra, M.,Lillywhite, J.,Muhandiram, D.R.,Gertler, F.,Terhorst, C.,Kay, L.E.,Pawson, T.,Forman-Kay, J.D.,Li, S.C.
A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
EMBO J., 21:314-323, 2002
PubMed: 11823424 (PDB entries with the same primary citation)
DOI: 10.1093/emboj/21.3.314
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers61.7%30.1%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload
PDB entries from 2020-09-16