6UK1

Crystal structure of nucleotide-binding domain 2 (NBD2) of the human Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

Summary for 6UK1

• Entry DOI: 10.2210/pdb6uk1/pdb
• Descriptor: Cystic fibrosis transmembrane conductance regulator, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: nbd2, cftr, abc transport, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 104335.13

Authors

Wang, C.,Vorobiev, S.M.,Vernon, R.M.,Khazanov, N.,Senderowitz, H.,Forman-Kay, J.D.,Hunt, J.F. (deposition date: 2019-10-03, release date: 2020-10-07, Last modification date: 2023-10-11)

• Primary citation: Wang, C.,Vorobiev, S.,Vernon, R.M.,Khazanov, N.,Senderowitz, H.,Forman-Kay, J.D.,Hunt, J.F.; A thermodynamically stabilized form of the second nucleotide binding domain from human CFTR shows a catalytically inactive conformation; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.693 Å)