6UK1
Crystal structure of nucleotide-binding domain 2 (NBD2) of the human Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cystic fibrosis transmembrane conductance regulator | polymer | 229 | 25552.3 | 4 | UniProt (P13569) Pfam (PF00005) | Homo sapiens (Human) | CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | E, G, I, K (A, B, C, D) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) | |||
| 3 | F, H, J, L (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 74 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1202 - 1430 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| Leu 1255 | Ser 1255 | engineered mutation |
| Glu 1280 | Gln 1280 | engineered mutation |
| Asp 1292 | Lys 1292 | engineered mutation |
| Asn 1307 | Tyr 1307 | engineered mutation |
| Gly 1334 | Lys 1334 | engineered mutation |
| Ala 1359 | Ser 1359 | engineered mutation |
| Ala 1402 | His 1402 | engineered mutation |
| Asp 1411 | Gln 1411 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 102209.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2125.9 | |
| All* | Total formula weight | 104335.1 |
