1JYQ

Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide

Summary for 1JYQ

Entry DOI	10.2210/pdb1jyq/pdb
Related	1JYR 1JYU
Related PRD ID	PRD_000409
Descriptor	GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, mAZ-pY-(alpha Me)pY-N-NH2 peptide inhibitor (3 entities in total)
Functional Keywords	receptor binding, regulatory, signaling protein-signaling protein inhibitor, signaling protein-peptide inhibitor complex, signaling protein/peptide inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	23674.32
Authors	Nioche, P.,Liu, W.-Q.,Broutin, I.,Charbonnier, F.,Latreille, M.-T.,Vidal, M.,Roques, B.,Garbay, C.,Ducruix, A. (deposition date: 2001-09-13, release date: 2002-03-13, Last modification date: 2018-04-04)
Primary citation	Nioche, P.,Liu, W.Q.,Broutin, I.,Charbonnier, F.,Latreille, M.T.,Vidal, M.,Roques, B.,Garbay, C.,Ducruix, A. Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315:1167-1177, 2002 Cited by PubMed: 11827484 DOI: 10.1006/jmbi.2001.5299 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation