1JYQ
Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR CHAIN L OF MAZ-PY-(ALPHA ME)PY-N-NH2 PEPTIDE INHIBITOR |
| Chain | Residue |
| A | ARG67 |
| A | HIS107 |
| A | PHE108 |
| A | LYS109 |
| A | LEU120 |
| A | SER141 |
| A | ARG142 |
| A | ASN143 |
| A | HOH334 |
| A | HOH404 |
| A | HOH443 |
| A | ARG78 |
| L | HOH370 |
| L | HOH382 |
| L | HOH452 |
| A | ARG86 |
| A | SER88 |
| A | SER90 |
| A | SER96 |
| A | PHE101 |
| A | ASN103 |
| A | GLN106 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR CHAIN H OF MAZ-PY-(ALPHA ME)PY-N-NH2 PEPTIDE INHIBITOR |
| Chain | Residue |
| B | ARG67 |
| B | ARG86 |
| B | SER88 |
| B | SER90 |
| B | SER96 |
| B | PHE101 |
| B | GLN106 |
| B | HIS107 |
| B | PHE108 |
| B | LYS109 |
| B | LYS109 |
| B | LEU111 |
| B | LEU120 |
| B | TRP121 |
| B | SER141 |
| B | ARG142 |
| B | ASN143 |
| B | HOH308 |
| H | HOH330 |
| H | HOH335 |
| H | HOH345 |
| H | HOH421 |
| H | HOH436 |
| H | HOH441 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"34348893","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
