1OPK

Structural basis for the auto-inhibition of c-Abl tyrosine kinase

Summary for 1OPK

Entry DOI	10.2210/pdb1opk/pdb
Related	1OPJ 1OPK
Descriptor	Proto-oncogene tyrosine-protein kinase ABL1, MYRISTIC ACID, 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, ... (5 entities in total)
Functional Keywords	transferase
Biological source	Mus musculus (house mouse)
Cellular location	Cytoplasm, cytoskeleton: P00520
Total number of polymer chains	1
Total formula weight	56936.91
Authors	Nagar, B.,Hantschel, O.,Young, M.A.,Scheffzek, K.,Veach, D.,Bornmann, W.,Clarkson, B.,Superti-Furga, G.,Kuriyan, J. (deposition date: 2003-03-06, release date: 2003-04-08, Last modification date: 2023-08-16)
Primary citation	Nagar, B.,Hantschel, O.,Young, M.A.,Scheffzek, K.,Veach, D.,Bornmann, W.,Clarkson, B.,Superti-Furga, G.,Kuriyan, J. Structural basis for the autoinhibition of c-Abl tyrosine kinase Cell(Cambridge,Mass.), 112:859-871, 2003 Cited by PubMed: 12654251 DOI: 10.1016/S0092-8674(03)00194-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation