1OPK
Structural basis for the auto-inhibition of c-Abl tyrosine kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proto-oncogene tyrosine-protein kinase ABL1 | polymer | 495 | 56189.2 | 1 | UniProt (P00520) Pfam (PF00018) Pfam (PF00017) Pfam (PF07714) | Mus musculus (house mouse) | p150, c-ABL |
| 2 | B (A) | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) | |||
| 3 | C (A) | 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE | non-polymer | 427.3 | 1 | Chemie (P16) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E (A) | water | water | 18.0 | 270 | Chemie (HOH) |
Sequence modifications
A: 46 - 534 (UniProt: P00520)
| PDB | External Database | Details |
|---|---|---|
| Gly 40 | - | cloning artifact |
| Ala 41 | - | cloning artifact |
| Met 42 | - | cloning artifact |
| Asp 43 | - | cloning artifact |
| Pro 44 | - | cloning artifact |
| Ser 45 | - | cloning artifact |
| Asn 382 | Asp 363 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 56189.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 747.7 | |
| All* | Total formula weight | 56936.9 |
