1OO3

P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase

Summary for 1OO3

Related1OO4
DescriptorPhosphatidylinositol 3-kinase regulatory alpha subunit (1 entity in total)
Functional Keywordssrc homology 2 domain p85 regulatory subunit mutant, protein binding
Biological sourceBos taurus (cattle)
Total number of polymer chains1
Total molecular weight12860.35
Authors
Guenther, U.L.,Weyrauch, B.,Schaffhausen, B. (deposition date: 2003-03-03, release date: 2003-03-25, Last modification date: 2011-07-13)
Primary citation
Guenther, U.L.,Weyrauch, B.,Zhang, X.,Schaffhausen, B.
Nuclear magnetic resonance structure of the P395S mutant of the N-SH2 domain of the p85 subunit of PI3 kinase: an SH2 domain with altered specificity
Biochemistry, 42:11120-11127, 2003
PubMed: 14503862 (PDB entries with the same primary citation)
DOI: 10.1021/bi034353x
MImport into Mendeley
Experimental method
SOLUTION NMR
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Structure validation

ClashscoreRamachandran outliersSidechain outliers06.4%15.2%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation report