3LVP
| Crystal structure of bisphosphorylated IGF1-R Kinase domain (2P) in complex with a bis-azaindole inhibitor | Descriptor: | 3-(4-chloro-1H-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1H-pyrrolo[3,2-b]pyridine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Insulin-like growth factor 1 receptor, ... | Authors: | Maignan, S, Marquette, J.P, Guilloteau, J.P. | Deposit date: | 2010-02-22 | Release date: | 2010-07-21 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Design of Potent IGF1-R Inhibitors Related to Bis-azaindoles Chem.Biol.Drug Des., 76, 2010
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7YRR
| Cryo-EM structure of IGF1R with two IGF1 complex | Descriptor: | Insulin-like growth factor 1 receptor, Isoform 3 of Insulin-like growth factor I | Authors: | Xi, Z, Cang, W. | Deposit date: | 2022-08-10 | Release date: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Cryo-EM structure of IGF1R with two IGF1 complex at 4.3 angstroms resolution To Be Published
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3D94
| Crystal structure of the insulin-like growth factor-1 receptor kinase in complex with PQIP | Descriptor: | 3-[cis-3-(4-methylpiperazin-1-yl)cyclobutyl]-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine, CALCIUM ION, Insulin-like growth factor 1 receptor beta chain | Authors: | Wu, J, Li, W, Miller, W.T, Hubbard, S.R. | Deposit date: | 2008-05-26 | Release date: | 2008-07-29 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor Embo J., 27, 2008
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7V3P
| Cryo-EM structure of the IGF1R/insulin complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ... | Authors: | Zhang, J, Liu, C, Zhang, X, Wei, T, Wu, C. | Deposit date: | 2021-08-11 | Release date: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure of the IGF1R/insulin complex To Be Published
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7XGD
| Cryo-EM structure of Apo-IGF1R map 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor 1 receptor | Authors: | Zhang, X, Wu, C. | Deposit date: | 2022-04-04 | Release date: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structure of Apo-IGF1R To Be Published
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7XLC
| conformation II of apo-IGF1R states | Descriptor: | Insulin-like growth factor 1 receptor | Authors: | Xi, Z, Cang, W. | Deposit date: | 2022-04-21 | Release date: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (5 Å) | Cite: | conformation II of apo-IGF1R states To Be Published
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8PYI
| Human IGF1R with inhibitor 6 | Descriptor: | 3-[8-azanyl-1-(4-ethoxy-8-fluoranyl-2-phenyl-quinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutan-1-ol, Insulin-like growth factor 1 receptor beta chain | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | Deposit date: | 2023-07-25 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.06 Å) | Cite: | Human IGF1R with inhibitor 6 To Be Published
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8PYJ
| Human IGF1R with inhibitor 8 | Descriptor: | 5,5-dimethyl-1-(quinolin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione, CADMIUM ION, Insulin-like growth factor 1 receptor beta chain, ... | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | Deposit date: | 2023-07-25 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.702 Å) | Cite: | Human IGF1R with inhibitor 8 To Be Published
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8PYK
| Human IGF1R with inhibitor 47 | Descriptor: | 5,5-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione, Insulin-like growth factor 1 receptor beta chain, NICKEL (II) ION | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | Deposit date: | 2023-07-25 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Human IGF1R with inhibitor 47 To Be Published
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8PYL
| Human IGF1R with inhibitor 53 | Descriptor: | (5S)-5-methyl-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione, CADMIUM ION, Insulin-like growth factor 1 receptor beta chain, ... | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | Deposit date: | 2023-07-25 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.93 Å) | Cite: | Human IGF1R with inhibitor 53 To Be Published
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8PYM
| Human IGF1R with inhibitor 54 | Descriptor: | 5,5-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione, CADMIUM ION, Insulin-like growth factor 1 receptor beta chain, ... | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | Deposit date: | 2023-07-25 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.652 Å) | Cite: | Human IGF1R with inhibitor 54 To Be Published
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8PYN
| Human IGF1R with inhibitor 56 | Descriptor: | 5,5-dimethyl-1-(1H-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione, CADMIUM ION, Insulin-like growth factor 1 receptor beta chain, ... | Authors: | Dreyer, M.K, Wang, J, Elkins, J.M. | Deposit date: | 2023-07-25 | Release date: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Human IGF1R with inhibitor 56 To Be Published
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8TAN
| CryoEM structure of MFRV-VILP bound to IGF1Rzip | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor, ... | Authors: | Kirk, N.S. | Deposit date: | 2023-06-27 | Release date: | 2024-01-17 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression. Mol Metab, 80, 2024
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6PYH
| Cryo-EM structure of full-length IGF1R-IGF1 complex. Only the extracellular region of the complex is resolved. | Descriptor: | Insulin-like growth factor 1 receptor, Insulin-like growth factor I | Authors: | Li, J, Choi, E, Yu, H.T, Bai, X.C. | Deposit date: | 2019-07-29 | Release date: | 2019-10-23 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural basis of the activation of type 1 insulin-like growth factor receptor. Nat Commun, 10, 2019
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8EYR
| Cryo-EM structure of two IGF1 bound full-length mouse IGF1R mutant (four glycine residues inserted in the alpha-CT; IGF1R-P674G4): symmetric conformation | Descriptor: | Insulin-like growth factor 1 receptor, Insulin-like growth factor I | Authors: | Li, J, Wu, J.Y, Hall, C, Bai, X.C, Choi, E. | Deposit date: | 2022-10-28 | Release date: | 2022-11-09 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Molecular basis for the role of disulfide-linked alpha CTs in the activation of insulin-like growth factor 1 receptor and insulin receptor. Elife, 11, 2022
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4XLV
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5E1S
| The Crystal structure of INSR Tyrosine Kinase in complex with the Inhibitor BI 885578 | Descriptor: | (5R)-N-(1-{2-[4-(2-methoxyethyl)piperazin-1-yl]ethyl}-1H-pyrazol-3-yl)-5,8-dimethyl-9-phenyl-6,8-dihydro-5H-pyrazolo[3,4-h]quinazolin-2-amine, Insulin receptor | Authors: | Kessler, D, Zahn, S, Sanderson, M, Wolkerstorfer, B. | Deposit date: | 2015-09-30 | Release date: | 2015-10-14 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.264 Å) | Cite: | BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis. Mol.Cancer Ther., 14, 2015
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1K3A
| Structure of the Insulin-like Growth Factor 1 Receptor Kinase | Descriptor: | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, insulin receptor substrate 1, insulin-like growth factor 1 receptor | Authors: | Favelyukis, S, Till, J.H, Hubbard, S.R, Miller, W.T. | Deposit date: | 2001-10-02 | Release date: | 2001-11-28 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and autoregulation of the insulin-like growth factor 1 receptor kinase. Nat.Struct.Biol., 8, 2001
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3O23
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7U23
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7WRQ
| Structure of Human IGF1/IGFBP3/ALS Ternary Complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor-binding protein 3, Insulin-like growth factor-binding protein complex acid labile subunit, ... | Authors: | Kim, H, Fu, Y, Kim, H.M. | Deposit date: | 2022-01-27 | Release date: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis for assembly and disassembly of the IGF/IGFBP/ALS ternary complex Nat Commun, 13, 2022
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2DSQ
| Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins | Descriptor: | Insulin-like growth factor IB, Insulin-like growth factor-binding protein 1, Insulin-like growth factor-binding protein 4 | Authors: | Sitar, T, Popowicz, G.M, Siwanowicz, I, Huber, R, Holak, T.A. | Deposit date: | 2006-07-05 | Release date: | 2006-08-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2DSR
| Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins | Descriptor: | Insulin-like growth factor IB, Insulin-like growth factor-binding protein 4 | Authors: | Sitar, T, Popowicz, G.M, Siwanowicz, I, Huber, R, Holak, T.A. | Deposit date: | 2006-07-05 | Release date: | 2006-08-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2DSP
| Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins | Descriptor: | Insulin-like growth factor IB, Insulin-like growth factor-binding protein 4 | Authors: | Sitar, T, Popowicz, G.M, Siwanowicz, I, Huber, R, Holak, T.A. | Deposit date: | 2006-07-05 | Release date: | 2006-08-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins. Proc.Natl.Acad.Sci.Usa, 103, 2006
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7S0Q
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