4XLV
Crystal structure of the activated insulin receptor tyrosine kinase dimer
Summary for 4XLV
Entry DOI | 10.2210/pdb4xlv/pdb |
Descriptor | Insulin receptor, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | tyrosine kinase, signal transduction, phosphoryl transfer, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 37911.83 |
Authors | Hubbard, S.R.,Li, S. (deposition date: 2015-01-13, release date: 2015-03-25, Last modification date: 2019-12-25) |
Primary citation | Cabail, M.Z.,Li, S.,Lemmon, E.,Bowen, M.E.,Hubbard, S.R.,Miller, W.T. The insulin and IGF1 receptor kinase domains are functional dimers in the activated state. Nat Commun, 6:6406-6406, 2015 Cited by PubMed: 25758790DOI: 10.1038/ncomms7406 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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