4XLV
Crystal structure of the activated insulin receptor tyrosine kinase dimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin receptor | polymer | 328 | 37358.0 | 1 | UniProt (P06213) Pfam (PF07714) | Homo sapiens (Human) | IR |
| 2 | B (A) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) | |||
| 3 | C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E (A) | water | water | 18.0 | 141 | Chemie (HOH) |
Sequence modifications
A: 956 - 1283 (UniProt: P06213)
| PDB | External Database | Details |
|---|---|---|
| Phe 965 | Tyr 992 | engineered mutation |
| Ser 981 | Cys 1008 | engineered mutation |
| Asn 1251 | Lys 1278 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37358.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 553.8 | |
| All* | Total formula weight | 37911.8 |
