3D94

Crystal structure of the insulin-like growth factor-1 receptor kinase in complex with PQIP

Summary for 3D94

Entry DOI	10.2210/pdb3d94/pdb
Descriptor	Insulin-like growth factor 1 receptor beta chain, CALCIUM ION, 3-[cis-3-(4-methylpiperazin-1-yl)cyclobutyl]-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine, ... (4 entities in total)
Functional Keywords	igf1rk, receptor tyrosine kinase, pqip, inhibitor, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphoprotein, transferase, transmembrane, tyrosine-protein kinase
Biological source	Homo sapiens (Human)
Cellular location	Membrane; Single-pass type I membrane protein: P08069
Total number of polymer chains	1
Total formula weight	34978.27
Authors	Wu, J.,Li, W.,Miller, W.T.,Hubbard, S.R. (deposition date: 2008-05-26, release date: 2008-07-29, Last modification date: 2023-08-30)
Primary citation	Wu, J.,Li, W.,Craddock, B.P.,Foreman, K.W.,Mulvihill, M.J.,Ji, Q.S.,Miller, W.T.,Hubbard, S.R. Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor Embo J., 27:1985-1994, 2008 Cited by PubMed: 18566589 DOI: 10.1038/emboj.2008.116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation