7U23

Single-chain LCDV-1 viral insulin-like peptide bound to IGF-1R ectodomain, leucine-zippered form

Summary for 7U23

• Entry DOI: 10.2210/pdb7u23/pdb
• EMDB information: 26306
• Descriptor: Insulin-like growth factor 1 receptor, single-chain LCDV-1 viral insulin-like peptide (2 entities in total)
• Functional Keywords: igf-1r ectodomain, inhibitor, viral insulin-like peptide, single-chain lcdv-1, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 231327.90

Authors

Kirk, N.S.,Lawrence, M.C. (deposition date: 2022-02-22, release date: 2022-11-16)

• Primary citation: Moreau, F.,Kirk, N.S.,Zhang, F.,Gelfanov, V.,List, E.O.,Chrudinova, M.,Venugopal, H.,Lawrence, M.C.,Jimenez, V.,Bosch, F.,Kopchick, J.J.,DiMarchi, R.D.,Altindis, E.,Ronald Kahn, C.; Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist.; Nat Commun, 13:6700-6700, 2022; PubMed: 36335114; DOI: 10.1038/s41467-022-34391-6

Experimental method

ELECTRON MICROSCOPY (4.6 Å)