PDB: 55 件ウェブページステータス検索Chemie searchBIRD

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8FYH	G4 RNA-mediated PRC2 dimer 分子名称: G4 RNA, Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, ... 著者 Song, J, Kasinath, V. 登録日 2023-01-26 公開日 2023-10-04 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science, 381, 2023
7Y0I	Solution structures of ASH1L PHD domain in complex with H3K4me2 peptide 分子名称: ALA-ARG-THR-MLY-GLN-THR-ALA-ARG-LYS-SER-THR-GLY-GLY-LYS-ALA, Histone-lysine N-methyltransferase ASH1L, ZINC ION 著者 Yu, M, Zeng, L. 登録日 2022-06-05 公開日 2022-10-12 実験手法 SOLUTION NMR 主引用文献 Structural insight into ASH1L PHD finger recognizing methylated histone H3K4 and promoting cell growth in prostate cancer. Front Oncol, 12, 2022
7W6J	The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me2 peptide 分子名称: Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... 著者 Zhao, L, Li, Y, Chen, Y. 登録日 2021-12-01 公開日 2022-09-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
6TUY	Human LSD1/CoREST bound to the quinazoline inhibitor MC4106 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Mattevi, A, Marrocco, B. 登録日 2020-01-08 公開日 2021-07-21 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur.J.Med.Chem., 237, 2022
6LUK	Crystal structure of the SAMD1 SAM domain in another crystal form 分子名称: Atherin, SULFATE ION 著者 Cao, Y, Zhou, Y, Wang, Z. 登録日 2020-01-29 公開日 2021-02-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.054 Å) 主引用文献 The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv, 7, 2021
6LUI	Crystal structure of the SAMD1 WH domain and DNA complex 分子名称: Atherin, DNA (5'-D(*AP*CP*CP*TP*GP*CP*GP*CP*AP*CP*CP*AP*T)-3'), DNA (5'-D(*AP*TP*GP*GP*TP*GP*CP*GP*CP*AP*GP*GP*T)-3') 著者 Zhou, Y, Cao, Y, Wang, Z. 登録日 2020-01-29 公開日 2021-02-03 最終更新日 2021-07-07 実験手法 X-RAY DIFFRACTION (1.781 Å) 主引用文献 The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv, 7, 2021
6LUJ	Crystal structure of the SAMD1 SAM domain 分子名称: Atherin, SULFATE ION 著者 Cao, Y, Zhou, Y, Wang, Z. 登録日 2020-01-29 公開日 2021-02-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv, 7, 2021
6M2M	A role for histone chaperone OsChz1 in histone recognition and deposition 分子名称: Expressed protein, GLYCEROL, Histone H2B.1, ... 著者 Luo, Q, Wang, B. 登録日 2020-02-28 公開日 2020-10-21 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 OsChz1 acts as a histone chaperone in modulating chromatin organization and genome function in rice. Nat Commun, 11, 2020
6E2H	Crystal structure of human Ash2L (SPRY domain and SDI motif) in complex with full length DPY-30 分子名称: Protein dpy-30 homolog, Set1/Ash2 histone methyltransferase complex subunit ASH2 著者 Joshi, M, Brunzelle, J.S, Couture, J.F. 登録日 2018-07-11 公開日 2018-08-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.236 Å) 主引用文献 Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation. Structure, 26, 2018
5Z8N	Crystal structure of Arabidopsis thaliana EBS C-terminal deletion construct in complex with an H3K4me2 peptide 分子名称: Chromatin remodeling protein EBS, H3K4me2 peptide, ZINC ION 著者 Yang, Z, Du, J. 登録日 2018-01-31 公開日 2018-07-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 EBS is a bivalent histone reader that regulates floral phase transition in Arabidopsis. Nat. Genet., 50, 2018
5YC3	Crystal structure of AL3 PHD finger bound to H3K4me2 分子名称: H3K4me2, PHD finger protein ALFIN-LIKE 3, ZINC ION 著者 Zhao, S, Zhang, B, Li, H. 登録日 2017-09-06 公開日 2018-01-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.601 Å) 主引用文献 Systematic Profiling of Histone Readers in Arabidopsis thaliana. Cell Rep, 22, 2018
5TDR	Set3 PHD finger in complex with histone H3K4me2 分子名称: Histone H3, SET domain-containing protein 3, SODIUM ION, ... 著者 Andrews, F.H, Ali, M, Kutateladze, T.G. 登録日 2016-09-19 公開日 2016-11-02 最終更新日 2017-06-28 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Structural Insight into Recognition of Methylated Histone H3K4 by Set3. J. Mol. Biol., 429, 2017
5TAB	Crystal Structure of the PHD Finger of PHF20 分子名称: GLYCEROL, PHD finger protein 20, ZINC ION 著者 Klein, B.J, Kutateladze, T.G. 登録日 2016-09-09 公開日 2016-10-26 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation. Cell Rep, 17, 2016
5TBN	Solution NMR structure of PHF20 PHD domain in complex with a histone H3K4me2 peptide 分子名称: Histone H3.1, PHD finger protein 20, ZINC ION 著者 Cui, G, Botuyan, M.V, Mer, G. 登録日 2016-09-12 公開日 2016-10-12 最終更新日 2019-12-04 実験手法 SOLUTION NMR 主引用文献 PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation. Cell Rep, 17, 2016
4UP5	Crystal structure of the Pygo2 PHD finger in complex with the B9L HD1 domain and a chemical fragment 分子名称: 6-methoxy-1,3-benzothiazol-2-amine, PYGOPUS HOMOLOG 2, B-CELL CLL/LYMPHOMA 9-LIKE PROTEIN, ... 著者 Miller, T.C.R, Fiedler, M, Rutherford, T.J, Birchall, K, Chugh, J, Bienz, M. 登録日 2014-06-12 公開日 2014-11-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Competitive Binding of a Benzimidazole to the Histone-Binding Pocket of the Pygo Phd Finger. Acs Chem.Biol., 9, 2014
4UP0	Ternary crystal structure of the Pygo2 PHD finger in complex with the B9L HD1 domain and a H3K4me2 peptide 分子名称: HISTONE H3.1, PYGOPUS HOMOLOG 2, B-CELL CLL/LYMPHOMA 9-LIKE PROTEIN, ... 著者 Miller, T.C.R, Fiedler, M, Rutherford, T.J, Birchall, K, Chugh, J, Bienz, M. 登録日 2014-06-11 公開日 2014-11-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Competitive Binding of a Benzimidazole to the Histone-Binding Pocket of the Pygo Phd Finger. Acs Chem.Biol., 9, 2014
2MNZ	NMR Structure of KDM5B PHD1 finger in complex with H3K4me0(1-10aa) 分子名称: H3K4me0, Lysine-specific demethylase 5B, ZINC ION 著者 Zhang, Y, Yang, H.R, Guo, X, Rong, N.Y, Song, Y.J, Xu, Y.W, Lan, W.X, Xu, Y.H, Cao, C. 登録日 2014-04-16 公開日 2014-08-06 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B. Protein Cell, 5, 2014
2MNY	NMR Structure of KDM5B PHD1 finger 分子名称: Lysine-specific demethylase 5B, ZINC ION 著者 Zhang, Y, Yang, H.R, Guo, X, Rong, N.Y, Song, Y.J, Xu, Y.W, Lan, W.X, Xu, Y.H, Cao, C. 登録日 2014-04-16 公開日 2014-08-06 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B. Protein Cell, 5, 2014
4C1Q	Crystal structure of the PRDM9 SET domain in complex with H3K4me2 and AdoHcy. 分子名称: GLYCEROL, HISTONE H3.1, HISTONE-LYSINE N-METHYLTRANSFERASE PRDM9, ... 著者 Mathioudakis, N, Cusack, S, Kadlec, J. 登録日 2013-08-13 公開日 2013-10-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular Basis for the Regulation of the H3K4 Methyltransferase Activity of Prdm9. Cell Rep., 5, 2013
4HSU	Crystal structure of LSD2-NPAC with H3(1-26)in space group P21 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Histone H3, Lysine-specific histone demethylase 1B, ... 著者 Chen, F, Dong, Z, Fang, J, Xu, Y. 登録日 2012-10-30 公開日 2013-02-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.988 Å) 主引用文献 Structural insight into substrate recognition by histone demethylase LSD2/KDM1b. Cell Res., 23, 2013
4FWE	Native structure of LSD2 /AOF1/KDM1b in spacegroup of C2221 at 2.13A 分子名称: CITRATE ANION, FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1B, ... 著者 Zhang, Q, Chen, Z. 登録日 2012-07-01 公開日 2013-01-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b Cell Res., 23, 2013
4GUS	Crystal structure of LSD2-NPAC with H3 in space group P3221 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Histone H3.3, ... 著者 Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y. 登録日 2012-08-29 公開日 2013-01-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013
4GUR	Crystal structure of LSD2-NPAC with H3 in space group P21 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Histone H3.3, ... 著者 Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y. 登録日 2012-08-29 公開日 2013-01-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.506 Å) 主引用文献 LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013
4FWF	Complex structure of LSD2/AOF1/KDM1b with H3K4 mimic 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Histone H3.1, Lysine-specific histone demethylase 1B, ... 著者 Zhang, Q, Chen, Z. 登録日 2012-07-01 公開日 2013-01-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b Cell Res., 23, 2013
4GUT	Crystal structure of LSD2-NPAC 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Lysine-specific histone demethylase 1B, ... 著者 Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Fang, R, Shi, Y, Xu, Y. 登録日 2012-08-29 公開日 2013-01-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.998 Å) 主引用文献 LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013

 

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