7Y0I

Solution structures of ASH1L PHD domain in complex with H3K4me2 peptide

Summary for 7Y0I

• Entry DOI: 10.2210/pdb7y0i/pdb
• Descriptor: Histone-lysine N-methyltransferase ASH1L, ALA-ARG-THR-MLY-GLN-THR-ALA-ARG-LYS-SER-THR-GLY-GLY-LYS-ALA, ZINC ION (3 entities in total)
• Functional Keywords: ash1l, phd domain, h3k4me2, prostate cancer, structural protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 8170.11

Authors

Yu, M.,Zeng, L. (deposition date: 2022-06-05, release date: 2022-10-12)

• Primary citation: Yu, M.,Jia, Y.,Ma, Z.,Ji, D.,Wang, C.,Liang, Y.,Zhang, Q.,Yi, H.,Zeng, L.; Structural insight into ASH1L PHD finger recognizing methylated histone H3K4 and promoting cell growth in prostate cancer.; Front Oncol, 12:906807-906807, 2022; PubMed: 36033518; DOI: 10.3389/fonc.2022.906807

Experimental method

SOLUTION NMR