6TUY

Human LSD1/CoREST bound to the quinazoline inhibitor MC4106

Summary for 6TUY

Entry DOI	10.2210/pdb6tuy/pdb
Descriptor	Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (9 entities in total)
Functional Keywords	epigenetics, histone demethylase, epigenetic inhibitor, dual inhibitor, oxidoreductase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	149324.00
Authors	Mattevi, A.,Marrocco, B. (deposition date: 2020-01-08, release date: 2021-07-21, Last modification date: 2024-01-24)
Primary citation	Menna, M.,Fiorentino, F.,Marrocco, B.,Lucidi, A.,Tomassi, S.,Cilli, D.,Romanenghi, M.,Cassandri, M.,Pomella, S.,Pezzella, M.,Del Bufalo, D.,Zeya Ansari, M.S.,Tomasevic, N.,Mladenovic, M.,Viviano, M.,Sbardella, G.,Rota, R.,Trisciuoglio, D.,Minucci, S.,Mattevi, A.,Rotili, D.,Mai, A. Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur.J.Med.Chem., 237:114410-114410, 2022 Cited by PubMed: 35525212 DOI: 10.1016/j.ejmech.2022.114410 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation