6TUY
Human LSD1/CoREST bound to the quinazoline inhibitor MC4106
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysine-specific histone demethylase 1A | polymer | 853 | 93108.6 | 1 | UniProt (O60341) Pfam (PF04433) Pfam (PF01593) | Homo sapiens (Human) | BRAF35-HDAC complex protein BHC110,Flavin-containing amine oxidase domain-containing protein 2 |
| 2 | B (B) | REST corepressor 1 | polymer | 485 | 53401.4 | 1 | UniProt (Q9UKL0) Pfam (PF01448) Pfam (PF00249) Pfam (PF20878) | Homo sapiens (Human) | Protein CoREST |
| 3 | C (A) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) | |||
| 4 | D, E, F (A) | ~{N}2-[3-(dimethylamino)propyl]-6,7-dimethoxy-~{N}4-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]quinazoline-2,4-diamine | non-polymer | 528.7 | 3 | Chemie (NY8) PubChem (156009002) | |||
| 5 | G (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) PubChem (1061) | |||
| 6 | H, I, J, K, L (A) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) PubChem (312) | |||
| 7 | M (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 8 | N (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) PubChem (679) | |||
| 9 | O, P (A, B) | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A: 1 - 868 (UniProt: O60341)
| PDB | External Database | Details |
|---|---|---|
| Pro 869 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 146509.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2814.1 | |
| All* | Total formula weight | 149324.0 |
