6TUY
Human LSD1/CoREST bound to the quinazoline inhibitor MC4106
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
A | 0000781 | cellular_component | chromosome, telomeric region |
A | 0000785 | cellular_component | chromatin |
A | 0002039 | molecular_function | p53 binding |
A | 0002052 | biological_process | positive regulation of neuroblast proliferation |
A | 0003682 | molecular_function | chromatin binding |
A | 0003713 | molecular_function | transcription coactivator activity |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005667 | cellular_component | transcription regulator complex |
A | 0005694 | cellular_component | chromosome |
A | 0006325 | biological_process | chromatin organization |
A | 0006338 | biological_process | chromatin remodeling |
A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
A | 0006482 | biological_process | protein demethylation |
A | 0010569 | biological_process | regulation of double-strand break repair via homologous recombination |
A | 0010718 | biological_process | positive regulation of epithelial to mesenchymal transition |
A | 0010976 | biological_process | positive regulation of neuron projection development |
A | 0014070 | biological_process | response to organic cyclic compound |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0019899 | molecular_function | enzyme binding |
A | 0021987 | biological_process | cerebral cortex development |
A | 0030374 | molecular_function | nuclear receptor coactivator activity |
A | 0031398 | biological_process | positive regulation of protein ubiquitination |
A | 0032091 | biological_process | negative regulation of protein binding |
A | 0032451 | molecular_function | demethylase activity |
A | 0032452 | molecular_function | histone demethylase activity |
A | 0032453 | molecular_function | histone H3K4 demethylase activity |
A | 0032454 | molecular_function | histone H3K9 demethylase activity |
A | 0032880 | biological_process | regulation of protein localization |
A | 0032991 | cellular_component | protein-containing complex |
A | 0034644 | biological_process | cellular response to UV |
A | 0036211 | biological_process | protein modification process |
A | 0042162 | molecular_function | telomeric DNA binding |
A | 0042551 | biological_process | neuron maturation |
A | 0042802 | molecular_function | identical protein binding |
A | 0043392 | biological_process | negative regulation of DNA binding |
A | 0043426 | molecular_function | MRF binding |
A | 0043433 | biological_process | negative regulation of DNA-binding transcription factor activity |
A | 0043518 | biological_process | negative regulation of DNA damage response, signal transduction by p53 class mediator |
A | 0045793 | biological_process | positive regulation of cell size |
A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
A | 0046098 | biological_process | guanine metabolic process |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
A | 0050681 | molecular_function | nuclear androgen receptor binding |
A | 0055001 | biological_process | muscle cell development |
A | 0060765 | biological_process | regulation of androgen receptor signaling pathway |
A | 0060992 | biological_process | response to fungicide |
A | 0061629 | molecular_function | RNA polymerase II-specific DNA-binding transcription factor binding |
A | 0061752 | molecular_function | telomeric repeat-containing RNA binding |
A | 0071320 | biological_process | cellular response to cAMP |
A | 0071480 | biological_process | cellular response to gamma radiation |
A | 0090308 | biological_process | regulation of DNA methylation-dependent heterochromatin formation |
A | 0120162 | biological_process | positive regulation of cold-induced thermogenesis |
A | 0140297 | molecular_function | DNA-binding transcription factor binding |
A | 0140682 | molecular_function | FAD-dependent H3K4me/H3K4me3 demethylase activity |
A | 0140861 | biological_process | DNA repair-dependent chromatin remodeling |
A | 1902166 | biological_process | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
A | 1990391 | cellular_component | DNA repair complex |
A | 1990841 | molecular_function | promoter-specific chromatin binding |
A | 2000179 | biological_process | positive regulation of neural precursor cell proliferation |
A | 2000648 | biological_process | positive regulation of stem cell proliferation |
B | 0000118 | cellular_component | histone deacetylase complex |
B | 0003682 | molecular_function | chromatin binding |
B | 0003714 | molecular_function | transcription corepressor activity |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005667 | cellular_component | transcription regulator complex |
B | 0006325 | biological_process | chromatin organization |
B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
B | 0010629 | biological_process | negative regulation of gene expression |
B | 0017053 | cellular_component | transcription repressor complex |
B | 0019899 | molecular_function | enzyme binding |
B | 0030218 | biological_process | erythrocyte differentiation |
B | 0045654 | biological_process | positive regulation of megakaryocyte differentiation |
B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
B | 1990391 | cellular_component | DNA repair complex |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 35 |
Details | binding site for residue FAD A 901 |
Chain | Residue |
A | GLY285 |
A | GLY315 |
A | ARG316 |
A | LEU329 |
A | GLY330 |
A | ALA331 |
A | MET332 |
A | VAL333 |
A | THR588 |
A | ALA589 |
A | VAL590 |
A | GLY287 |
A | THR624 |
A | LEU625 |
A | PRO626 |
A | TRP756 |
A | SER760 |
A | TYR761 |
A | GLY800 |
A | GLU801 |
A | ALA809 |
A | THR810 |
A | VAL288 |
A | VAL811 |
A | ALA814 |
A | NY8902 |
A | HOH1001 |
A | HOH1004 |
A | HOH1005 |
A | SER289 |
A | LEU307 |
A | GLU308 |
A | ALA309 |
A | ARG310 |
A | GLY314 |
site_id | AC2 |
Number of Residues | 12 |
Details | binding site for residue NY8 A 902 |
Chain | Residue |
A | ASN383 |
A | LEU386 |
A | ASN535 |
A | LEU536 |
A | PHE538 |
A | ALA539 |
A | ASN540 |
A | TRP552 |
A | ASP555 |
A | ASP556 |
A | FAD901 |
A | NY8903 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue NY8 A 903 |
Chain | Residue |
A | GLN358 |
A | ALA539 |
A | ASP556 |
A | GLU559 |
A | NY8902 |
A | NY8904 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue NY8 A 904 |
Chain | Residue |
A | ASP557 |
A | PHE558 |
A | GLU559 |
A | NY8903 |
site_id | AC5 |
Number of Residues | 7 |
Details | binding site for residue PO4 A 905 |
Chain | Residue |
A | LYS469 |
A | PRO471 |
A | LYS631 |
A | GLN652 |
A | ARG653 |
A | MET654 |
A | ALA765 |
site_id | AC6 |
Number of Residues | 1 |
Details | binding site for residue CL A 906 |
Chain | Residue |
A | ARG472 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue CL A 907 |
Chain | Residue |
A | GLU413 |
A | ARG526 |
A | ARG688 |
site_id | AC8 |
Number of Residues | 3 |
Details | binding site for residue CL A 910 |
Chain | Residue |
A | ARG310 |
A | ARG312 |
A | GOL911 |
site_id | AC9 |
Number of Residues | 3 |
Details | binding site for residue GOL A 911 |
Chain | Residue |
A | ARG310 |
A | TRP756 |
A | CL910 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue DMS A 912 |
Chain | Residue |
A | ARG750 |
A | TRP751 |
A | ASP754 |
A | HOH1007 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
B | SER124 | |
A | GLU308 | |
A | ARG310 | |
A | ARG316 | |
A | MET332 | |
A | GLU801 | |
A | THR810 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
B | SER257 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
B | SER457 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
B | LYS119 | |
B | LYS294 | |
B | LYS463 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER131 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | TYR135 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER137 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER166 |
site_id | SWS_FT_FI9 |
Number of Residues | 3 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:27292636 |
Chain | Residue | Details |
A | LYS432 | |
A | LYS433 | |
A | LYS436 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER611 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231 |
Chain | Residue | Details |
A | SER865 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS442 | |
A | LYS469 |
site_id | SWS_FT_FI13 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:25018020 |
Chain | Residue | Details |
A | LYS503 |