6W5M
| Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class02) | Descriptor: | DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... | Authors: | Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. | Deposit date: | 2020-03-13 | Release date: | 2021-03-31 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
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6WOV
| Cryo-EM structure of recombinant mouse Ryanodine Receptor type 2 wild type in complex with FKBP12.6 | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ZINC ION | Authors: | Iyer, K.A, Hu, Y, Nayak, A.R, Kurebayashi, N, Murayama, T, Samso, M. | Deposit date: | 2020-04-25 | Release date: | 2020-08-05 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (5.1 Å) | Cite: | Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM. Sci Adv, 6, 2020
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6WOU
| Cryo-EM structure of recombinant mouse Ryanodine Receptor type 2 mutant R176Q in complex with FKBP12.6 in nanodisc | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ZINC ION | Authors: | Iyer, K.A, Hu, Y, Kurebayashi, N, Murayama, T, Samso, M. | Deposit date: | 2020-04-25 | Release date: | 2020-08-05 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM. Sci Adv, 6, 2020
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6WOT
| Cryo-EM structure of recombinant rabbit Ryanodine Receptor type 1 mutant R164C in complex with FKBP12.6 | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ZINC ION | Authors: | Iyer, K.A, Hu, Y, Kurebayashi, N, Murayama, T, Samso, M. | Deposit date: | 2020-04-25 | Release date: | 2020-08-05 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM. Sci Adv, 6, 2020
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7M6A
| High resolution structure of the membrane embedded skeletal muscle ryanodine receptor | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... | Authors: | Melville, Z, Kim, K, Clarke, O.B, Marks, A.R. | Deposit date: | 2021-03-25 | Release date: | 2021-09-08 | Last modified: | 2022-01-19 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor. Structure, 30, 2022
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7M6L
| High resolution structure of the membrane embedded skeletal muscle ryanodine receptor | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... | Authors: | Melville, Z, Kim, K, Clarke, O.B, Marks, A.R. | Deposit date: | 2021-03-25 | Release date: | 2021-08-18 | Last modified: | 2022-01-19 | Method: | ELECTRON MICROSCOPY (3.98 Å) | Cite: | High-resolution structure of the membrane-embedded skeletal muscle ryanodine receptor. Structure, 30, 2022
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7MBN
| Cryo-EM structure of MLL1-NCP (H3K4M) complex, mode02 | Descriptor: | DNA (146-MER), Histone H2A, Histone H2B 1.1, ... | Authors: | Park, S.H, Ayoub, A, Lee, Y.T, Dou, Y, Cho, U. | Deposit date: | 2021-04-01 | Release date: | 2021-12-29 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY | Cite: | Regulation of MLL1 Methyltransferase Activity in Two Distinct Nucleosome Binding Modes. Biochemistry, 61, 2022
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7MBM
| Cryo-EM structure of MLL1-NCP (H3K4M) complex, mode01 | Descriptor: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | Authors: | Park, S.H, Ayoub, A, Lee, Y.T, Dou, Y, Cho, U. | Deposit date: | 2021-04-01 | Release date: | 2021-12-29 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY | Cite: | Regulation of MLL1 Methyltransferase Activity in Two Distinct Nucleosome Binding Modes. Biochemistry, 61, 2022
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7NSB
| Supramolecular assembly module of yeast Chelator-GID SR4 E3 ubiquitin ligase | Descriptor: | Glucose-induced degradation protein 7, Glucose-induced degradation protein 8, Vacuolar import and degradation protein 30 | Authors: | Chrustowicz, J, Sherpa, D, Prabu, J.R, Schulman, B.A. | Deposit date: | 2021-03-05 | Release date: | 2021-05-05 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Mol.Cell, 81, 2021
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7NSC
| Substrate receptor scaffolding module of human CTLH E3 ubiquitin ligase | Descriptor: | Glucose-induced degradation protein 4 homolog, Glucose-induced degradation protein 8 homolog, Isoform 2 of Armadillo repeat-containing protein 8, ... | Authors: | Chrustowicz, J, Sherpa, D, Prabu, J.R, Schulman, B.A. | Deposit date: | 2021-03-05 | Release date: | 2021-05-05 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme. Mol.Cell, 81, 2021
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8DUJ
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8DRP
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8DTB
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8DVE
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8DVV
| Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under open-state conditions | Descriptor: | CALCIUM ION, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... | Authors: | Iyer, K.A, Hu, Y, Murayama, T, Samso, M. | Deposit date: | 2022-07-29 | Release date: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Recombinant mouse RyR2 triple phosphomimetic mutant S2807D/S2813D/S2030D in complex with FKBP12.6 and nanodisc under open-state conditions To Be Published
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8DTY
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8DTZ
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8OKX
| Structure of cGAS in complex with SPSB3-ELOBC | Descriptor: | Cyclic GMP-AMP synthase, Elongin-B, Elongin-C, ... | Authors: | Xu, P.B, Ablasser, A. | Deposit date: | 2023-03-29 | Release date: | 2024-02-14 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.51 Å) | Cite: | The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation. Nature, 627, 2024
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8OL1
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8VK3
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8UQ2
| Structure of human RyR2-S2808D in the subprimed state | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 2, ... | Authors: | Miotto, M.C, Marks, A.R. | Deposit date: | 2023-10-23 | Release date: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders To Be Published
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8UQ5
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8UQ3
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8UQ4
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8UXE
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