8OKX
Structure of cGAS in complex with SPSB3-ELOBC
Summary for 8OKX
Entry DOI | 10.2210/pdb8okx/pdb |
EMDB information | 16933 |
Descriptor | Cyclic GMP-AMP synthase, SPRY domain-containing SOCS box protein 3, Elongin-C, ... (5 entities in total) |
Functional Keywords | cgas, degradation, ups, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 95827.71 |
Authors | Xu, P.B.,Ablasser, A. (deposition date: 2023-03-29, release date: 2024-02-14, Last modification date: 2024-04-10) |
Primary citation | Xu, P.,Liu, Y.,Liu, C.,Guey, B.,Li, L.,Melenec, P.,Ricci, J.,Ablasser, A. The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation. Nature, 627:873-879, 2024 Cited by PubMed: 38418882DOI: 10.1038/s41586-024-07112-w PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.51 Å) |
Structure validation
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