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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8OKX

Structure of cGAS in complex with SPSB3-ELOBC

Functional Information from GO Data
ChainGOidnamespacecontents
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000151cellular_componentubiquitin ligase complex
C0001222molecular_functiontranscription corepressor binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006351biological_processDNA-templated transcription
C0006357biological_processregulation of transcription by RNA polymerase II
C0006367biological_processtranscription initiation at RNA polymerase II promoter
C0006511biological_processubiquitin-dependent protein catabolic process
C0016567biological_processprotein ubiquitination
C0030674molecular_functionprotein-macromolecule adaptor activity
C0031462cellular_componentCul2-RING ubiquitin ligase complex
C0031466cellular_componentCul5-RING ubiquitin ligase complex
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0070449cellular_componentelongin complex
C0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
C0140958biological_processtarget-directed miRNA degradation
C1990116biological_processribosome-associated ubiquitin-dependent protein catabolic process
C2000104biological_processnegative regulation of DNA-templated DNA replication
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000151cellular_componentubiquitin ligase complex
D0001222molecular_functiontranscription corepressor binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006351biological_processDNA-templated transcription
D0006367biological_processtranscription initiation at RNA polymerase II promoter
D0006368biological_processtranscription elongation by RNA polymerase II
D0016567biological_processprotein ubiquitination
D0030891cellular_componentVCB complex
D0031462cellular_componentCul2-RING ubiquitin ligase complex
D0031466cellular_componentCul5-RING ubiquitin ligase complex
D0031625molecular_functionubiquitin protein ligase binding
D0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0065003biological_processprotein-containing complex assembly
D0070449cellular_componentelongin complex
D0140627biological_processubiquitin-dependent protein catabolic process via the C-end degron rule pathway
D0140958biological_processtarget-directed miRNA degradation
D1990116biological_processribosome-associated ubiquitin-dependent protein catabolic process
D2000104biological_processnegative regulation of DNA-templated DNA replication
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues42
DetailsRegion: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23707061","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues41
DetailsRegion: {"description":"Interaction with collided ribosomes","evidences":[{"source":"PubMed","id":"34111399","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues23
DetailsRegion: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"23707061","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues5
DetailsMotif: {"description":"Nuclear export signal","evidences":[{"source":"PubMed","id":"33406424","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues10
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"30356214","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsMotif: {"description":"KRKR-loop","evidences":[{"source":"PubMed","id":"31142647","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsMotif: {"description":"KKH-loop","evidences":[{"source":"PubMed","id":"31142647","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23722159","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26229115","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6CT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31113940","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4O67","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23707061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24332030","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28934246","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28940468","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31113940","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31142647","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32912999","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5V8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EDC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NFG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Y5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Y5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23707061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24332030","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28934246","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28940468","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31113940","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31142647","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32459092","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32911482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32912999","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5V8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VDW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EDC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6LRC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MJX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NAO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NFG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O47","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Y5D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6Y5E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C0M","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24462292","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6CTA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues2
DetailsSite: {"description":"Important for preferential detection of curved long DNA","evidences":[{"source":"PubMed","id":"30007416","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsSite: {"description":"Arginine-anchor","evidences":[{"source":"PubMed","id":"32911482","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32912999","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33051594","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsSite: {"description":"Cleavage; by CASP3","evidences":[{"source":"PubMed","id":"30878284","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsModified residue: {"description":"PolyADP-ribosyl aspartic acid","evidences":[{"source":"PubMed","id":"35460603","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) Deamidated asparagine; by herpes simplex virus 1/HHV-1 UL37","evidences":[{"source":"PubMed","id":"30092200","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"33273464","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by BLK","evidences":[{"source":"PubMed","id":"30356214","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues1
DetailsModified residue: {"description":"5-glutamyl polyglutamate","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by CDK1 and PKB","evidences":[{"source":"PubMed","id":"26440888","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32351706","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33542149","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues1
DetailsModified residue: {"description":"5-glutamyl glutamate","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues3
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"30799039","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"30799039","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"32474700","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues2
DetailsModified residue: {"description":"(Microbial infection) Deamidated glutamine; by herpes simplex virus 1/HHV-1 UL37","evidences":[{"source":"PubMed","id":"30092200","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues1
DetailsModified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"35210392","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues2
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"37802025","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues1
DetailsLipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"35438208","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"28273161","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI35
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"27637147","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI36
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"27637147","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI37
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"27637147","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI38
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI39
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"28273161","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI40
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"UniProtKB","id":"Q8C6L5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI41
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"35503863","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI42
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"27666593","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI43
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"38418882","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI44
Number of Residues51
DetailsDomain: {"description":"SOCS box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00194","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI45
Number of Residues65
DetailsDomain: {"description":"Ubiquitin-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00214","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI46
Number of Residues1
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI47
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62869","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2026-01-28

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