8OKX
Structure of cGAS in complex with SPSB3-ELOBC
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cyclic GMP-AMP synthase | polymer | 367 | 42714.1 | 1 | UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266) In PDB | Homo sapiens (human) | cGAMP synthase,cGAS,h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | B | SPRY domain-containing SOCS box protein 3 | polymer | 244 | 27415.2 | 1 | UniProt (Q6PJ21) Pfam (PF00622) In PDB | Homo sapiens (human) | SSB-3 |
| 3 | C | Elongin-C | polymer | 112 | 12485.1 | 1 | UniProt (Q15369) Pfam (PF03931) In PDB | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 4 | D | Elongin-B | polymer | 118 | 13147.8 | 1 | UniProt (Q15370) Pfam (PF00240) In PDB | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 5 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 156 - 522 (UniProt: Q8N884)
| PDB | External Database | Details |
|---|---|---|
| Ala 285 | Lys 285 | engineered mutation |
| Ala 300 | Arg 300 | engineered mutation |
| Ala 428 | Lys 428 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 95762.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 95827.7 |
