6WOU

Cryo-EM structure of recombinant mouse Ryanodine Receptor type 2 mutant R176Q in complex with FKBP12.6 in nanodisc

This is a non-PDB format compatible entry.

Summary for 6WOU

• Entry DOI: 10.2210/pdb6wou/pdb
• EMDB information: 21860 21861 21862
• Descriptor: Ryanodine receptor 2, Peptidyl-prolyl cis-trans isomerase FKBP1B, ZINC ION (3 entities in total)
• Functional Keywords: ryanodine receptor, calcium channel, mutation, ntda mutation, ryr2, polymorphic catecholergic ventricular tachycardia, arrhythmogenic right ventricular dysplasia 2, transport protein-isomerase complex, transport protein/isomerase
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 8
• Total formula weight: 2308958.86

Authors

Iyer, K.A.,Hu, Y.,Kurebayashi, N.,Murayama, T.,Samso, M. (deposition date: 2020-04-25, release date: 2020-08-05, Last modification date: 2022-08-03)

• Primary citation: Iyer, K.A.,Hu, Y.,Nayak, A.R.,Kurebayashi, N.,Murayama, T.,Samso, M.; Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM.; Sci Adv, 6:eabb2964-eabb2964, 2020; PubMed: 32832689; DOI: 10.1126/sciadv.abb2964

Experimental method

ELECTRON MICROSCOPY (3.27 Å)