6WOT
Cryo-EM structure of recombinant rabbit Ryanodine Receptor type 1 mutant R164C in complex with FKBP12.6
This is a non-PDB format compatible entry.
Summary for 6WOT
| Entry DOI | 10.2210/pdb6wot/pdb |
| EMDB information | 21860 21861 21862 |
| Descriptor | Ryanodine receptor 1, Peptidyl-prolyl cis-trans isomerase FKBP1B, ZINC ION (3 entities in total) |
| Functional Keywords | ryanodine receptor, calcium channel, mutation, ntda mutation, ryr1, malignant hyperthermia, central core disease, transport protein-isomerase complex, transport protein/isomerase |
| Biological source | Oryctolagus cuniculus (Rabbit) More |
| Total number of polymer chains | 8 |
| Total formula weight | 2309880.86 |
| Authors | Iyer, K.A.,Hu, Y.,Kurebayashi, N.,Murayama, T.,Samso, M. (deposition date: 2020-04-25, release date: 2020-08-05, Last modification date: 2022-08-03) |
| Primary citation | Iyer, K.A.,Hu, Y.,Nayak, A.R.,Kurebayashi, N.,Murayama, T.,Samso, M. Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM. Sci Adv, 6:eabb2964-eabb2964, 2020 Cited by PubMed: 32832689DOI: 10.1126/sciadv.abb2964 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.54 Å) |
Structure validation
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