7NSC

Substrate receptor scaffolding module of human CTLH E3 ubiquitin ligase

Summary for 7NSC

• Entry DOI: 10.2210/pdb7nsc/pdb
• EMDB information: 12537 12542 12545 12547 12564
• Descriptor: Ran-binding protein 9, Isoform 2 of Armadillo repeat-containing protein 8, Glucose-induced degradation protein 8 homolog, ... (4 entities in total)
• Functional Keywords: gid, ctlh, ubiquitin, e3 ligase, supramolecular assembly, metabolism, gluconeogenesis, cryoem, ligase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 216365.98

Authors

Chrustowicz, J.,Sherpa, D.,Prabu, J.R.,Schulman, B.A. (deposition date: 2021-03-05, release date: 2021-05-05, Last modification date: 2024-07-10)

• Primary citation: Sherpa, D.,Chrustowicz, J.,Qiao, S.,Langlois, C.R.,Hehl, L.A.,Gottemukkala, K.V.,Hansen, F.M.,Karayel, O.,von Gronau, S.,Prabu, J.R.,Mann, M.,Alpi, A.F.,Schulman, B.A.; GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme.; Mol.Cell, 81:2445-, 2021; PubMed: 33905682; DOI: 10.1016/j.molcel.2021.03.025

Experimental method

ELECTRON MICROSCOPY (3.3 Å)