7NSC

Substrate receptor scaffolding module of human CTLH E3 ubiquitin ligase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000151	cellular_component	ubiquitin ligase complex
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005875	cellular_component	microtubule associated complex
A	0005886	cellular_component	plasma membrane
A	0007010	biological_process	cytoskeleton organization
A	0007020	biological_process	microtubule nucleation
A	0016020	cellular_component	membrane
A	0016604	cellular_component	nuclear body
A	0019899	molecular_function	enzyme binding
A	0031267	molecular_function	small GTPase binding
A	0065003	biological_process	protein-containing complex assembly
A	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
A	1902993	biological_process	positive regulation of amyloid precursor protein catabolic process
D	0000151	cellular_component	ubiquitin ligase complex
D	0005829	cellular_component	cytosol
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0061630	molecular_function	ubiquitin protein ligase activity
E	0000151	cellular_component	ubiquitin ligase complex
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0034657	cellular_component	GID complex
E	0035580	cellular_component	specific granule lumen
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	1904724	cellular_component	tertiary granule lumen
H	0000151	cellular_component	ubiquitin ligase complex
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0008284	biological_process	positive regulation of cell population proliferation
H	0016055	biological_process	Wnt signaling pathway
H	0030054	cellular_component	cell junction
H	0042803	molecular_function	protein homodimerization activity
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0090263	biological_process	positive regulation of canonical Wnt signaling pathway

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	SITE: Interaction with the N-terminal Pro (Pro/N-degron) of proteins that are targeted for degradation => ECO:0000269|PubMed:29632410

Chain	Residue	Details
D	GLN132
D	GLU237
D	TYR258

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
E	SER323
E	SER498

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	SER487

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