8OL1

cGAS-Nucleosome in complex with SPSB3-ELOBC (composite structure)

Summary for 8OL1

• Entry DOI: 10.2210/pdb8ol1/pdb
• EMDB information: 16933 16936 16937
• Descriptor: Histone H3.2, SPRY domain-containing SOCS box protein 3, Elongin-C, ... (13 entities in total)
• Functional Keywords: cgas, degradation, ups, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 14
• Total formula weight: 270832.25

Authors

Xu, P.B.,Ablasser, A. (deposition date: 2023-03-29, release date: 2024-02-14, Last modification date: 2024-04-10)

• Primary citation: Xu, P.,Liu, Y.,Liu, C.,Guey, B.,Li, L.,Melenec, P.,Ricci, J.,Ablasser, A.; The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation.; Nature, 627:873-879, 2024; PubMed: 38418882; DOI: 10.1038/s41586-024-07112-w

Experimental method

ELECTRON MICROSCOPY (3.5 Å)