8OL1
cGAS-Nucleosome in complex with SPSB3-ELOBC (composite structure)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Histone H3.2 | polymer | 98 | 11546.5 | 2 | UniProt (Q71DI3) Pfam (PF00125) | Homo sapiens (human) | H3-clustered histone 13,H3-clustered histone 14,H3-clustered histone 15,Histone H3/m,Histone H3/o |
| 2 | B, F (B, F) | Histone H4 | polymer | 81 | 9180.7 | 2 | UniProt (P62805) Pfam (PF15511) | Homo sapiens (human) | |
| 3 | C (C) | Histone H2A type 1-H | polymer | 108 | 11763.8 | 1 | UniProt (Q96KK5) Pfam (PF00125) Pfam (PF16211) | Homo sapiens (human) | H2A-clustered histone 12,Histone H2A/s |
| 4 | D (D) | Histone H2B type 1-H | polymer | 95 | 10623.2 | 1 | UniProt (Q93079) Pfam (PF00125) | Homo sapiens (human) | H2B-clustered histone 9,Histone H2B.j,H2B/j |
| 5 | G (G) | Histone H2A type 1-J | polymer | 107 | 11666.6 | 1 | UniProt (Q99878) Pfam (PF00125) Pfam (PF16211) | Homo sapiens (human) | Histone H2A/e |
| 6 | H (H) | Histone H2B type 1-N | polymer | 94 | 10494.0 | 1 | UniProt (Q99877) Pfam (PF00125) | Homo sapiens (human) | Histone H2B.d,H2B/d |
| 7 | I (I) | DNA (145-MER) | polymer | 145 | 44552.4 | 1 | Homo sapiens | ||
| 8 | J (J) | DNA (145-MER) | polymer | 145 | 44961.6 | 1 | Homo sapiens | ||
| 9 | K (K) | Cyclic GMP-AMP synthase | polymer | 362 | 42202.6 | 1 | UniProt (Q8N884) Pfam (PF20266) Pfam (PF03281) | Homo sapiens (human) | cGAMP synthase,cGAS,h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 10 | L (L) | SPRY domain-containing SOCS box protein 3 | polymer | 244 | 27415.2 | 1 | UniProt (Q6PJ21) Pfam (PF00622) | Homo sapiens (human) | SSB-3 |
| 11 | M (M) | Elongin-C | polymer | 112 | 12485.1 | 1 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 12 | N (N) | Elongin-B | polymer | 118 | 13147.8 | 1 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 13 | O (K) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
K: 161 - 522 (UniProt: Q8N884)
| PDB | External Database | Details |
|---|---|---|
| Ala 285 | Lys 285 | engineered mutation |
| Ala 300 | Arg 300 | engineered mutation |
| Ala 428 | Lys 428 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 270766.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 270832.2 |
