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5ACQ
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BU of 5acq by Molmil
W228A-Investigation of the impact from residues W228 and Y233 in the metallo-beta-lactamase GIM-1
Descriptor: BETA-LACTAMASE, ZINC ION
Authors:Skagseth, S, Carlsen, T.J, Bjerga, G.E.K, Spencer, J, Samuelsen, O, Leiros, H.-K.S.
Deposit date:2015-08-17
Release date:2015-12-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Role of Residues W228 and Y233 in the Structure and Activity of Metallo-Beta-Lactamase Gim-1.
Antimicrob.Agents Chemother., 60, 2015
5A87
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BU of 5a87 by Molmil
Crystal structure of the metallo-beta-lactamase VIM-5
Descriptor: GLYCEROL, METALLO-BETA-LACTAMASE VIM-5, ZINC ION
Authors:Brem, J, Duzgun, A.O, McDonough, M.A, Schofield, C.J.
Deposit date:2015-07-13
Release date:2015-12-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Comparison of Verona Integron-Borne Metallo-beta-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles.
Antimicrob. Agents Chemother., 60, 2015
5ACT
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BU of 5act by Molmil
W228S-Investigation of the impact from residues W228 and Y233 in the metallo-beta-lactamase GIM-1
Descriptor: GIM-1 PROTEIN, ZINC ION
Authors:Skagseth, S, Carlsen, T.J, Bjerga, G.E.K, Spencer, J, Samuelsen, O, Leiros, H.-K.S.
Deposit date:2015-08-17
Release date:2015-12-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Role of Residues W228 and Y233 in the Structure and Activity of Metallo-Beta-Lactamase Gim-1.
Antimicrob.Agents Chemother., 60, 2015
8R5U
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BU of 8r5u by Molmil
VIM-2 metallo-beta-lactamase in complex with benzebisheterocycle compound 14
Descriptor: Beta-lactamase VIM-2, FORMIC ACID, ZINC ION, ...
Authors:Hinchliffe, P, Spencer, J.
Deposit date:2023-11-17
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Rational Design of Benzobisheterocycle Metallo-beta-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.
J.Med.Chem., 67, 2024
8R5T
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BU of 8r5t by Molmil
Crystal structure of NDM-1 in complex with benzobisheterocycle compound 14.
Descriptor: Metallo-beta-lactamase type 2, SULFATE ION, ZINC ION, ...
Authors:Hinchliffe, P, Spencer, J.
Deposit date:2023-11-17
Release date:2024-04-10
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Rational Design of Benzobisheterocycle Metallo-beta-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.
J.Med.Chem., 67, 2024
8SK2
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BU of 8sk2 by Molmil
X-ray structure of the NDM-4 beta-lactamase from Klebsiella pneumonia, apo form
Descriptor: 1,2-ETHANEDIOL, Metallo-beta-lactamase type 2, ZINC ION
Authors:Thoden, J.B, Holden, H.M.
Deposit date:2023-04-18
Release date:2023-08-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Characterization of a novel inhibitor for the New Delhi metallo-beta-lactamase-4: Implications for drug design and combating bacterial drug resistance.
J.Biol.Chem., 299, 2023
4NQ6
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BU of 4nq6 by Molmil
Bacillus cereus Zn-dependent metallo-beta-lactamase at pH 7 complexed with compound L-CS319
Descriptor: (3S,5S,7aR)-5-(sulfanylmethyl)tetrahydro[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid, Beta-lactamase 2, POTASSIUM ION, ...
Authors:Gonzalez, J.M, Gonzalez, M.M, Vila, A.J.
Deposit date:2013-11-23
Release date:2014-11-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Cross-class metallo-beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
4LE6
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BU of 4le6 by Molmil
Crystal structure of the phosphotriesterase OPHC2 from Pseudomonas pseudoalcaligenes
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Organophosphorus hydrolase, ...
Authors:Gotthard, G, Hiblot, J, Chabriere, E, Elias, M.
Deposit date:2013-06-25
Release date:2013-11-13
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Enzymatic Characterization of the Phosphotriesterase OPHC2 from Pseudomonas pseudoalcaligenes.
Plos One, 8, 2013
8SKP
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BU of 8skp by Molmil
X-ray structure of the NDM-4 beta-lactamase from Klebsiella pneumonia in complex with 1-hydroxypyridine-2(1H)-thione-6-carboxylic acid
Descriptor: 1,2-ETHANEDIOL, 1-hydroxy-6-sulfanylidene-1,6-dihydropyridine-2-carboxylic acid, Metallo-beta-lactamase type 2, ...
Authors:Thoden, J.B, Holden, H.M.
Deposit date:2023-04-20
Release date:2023-08-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Characterization of a novel inhibitor for the New Delhi metallo-beta-lactamase-4: Implications for drug design and combating bacterial drug resistance.
J.Biol.Chem., 299, 2023
8SKO
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BU of 8sko by Molmil
X-ray structure of the NDM-4 beta-lactamase from Klebsiella pneumonia with L-Captopril bound
Descriptor: L-CAPTOPRIL, Metallo-beta-lactamase type 2, ZINC ION
Authors:Thoden, J.B, Holden, H.M.
Deposit date:2023-04-20
Release date:2023-08-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Characterization of a novel inhibitor for the New Delhi metallo-beta-lactamase-4: Implications for drug design and combating bacterial drug resistance.
J.Biol.Chem., 299, 2023
4NQ4
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BU of 4nq4 by Molmil
Bacillus cereus Zn-dependent metallo-beta-lactamase at pH 7
Descriptor: Beta-lactamase 2, POTASSIUM ION, ZINC ION
Authors:Gonzalez, J.M, Gonzalez, M.M, Vila, A.J.
Deposit date:2013-11-23
Release date:2014-11-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Inhibition of metallo-lactamases with bicyclic compounds
TO BE PUBLISHED
8U00
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BU of 8u00 by Molmil
Crystal structure of metallo-beta-lactamase superfamily protein from Caulobacter vibrioides
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ...
Authors:Kim, Y, Maltseva, N, Endres, M, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:2023-08-28
Release date:2023-09-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of metallo-beta-lactamase superfamily protein from Caulobacter vibrioides
To Be Published
4O98
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BU of 4o98 by Molmil
Crystal structure of Pseudomonas oleovorans PoOPH mutant H250I/I263W
Descriptor: ZINC ION, organophosphorus hydrolase
Authors:Luo, X.J, Kong, X.D, Zhao, J, Chen, Q, Zhou, J.H, Xu, J.H.
Deposit date:2014-01-02
Release date:2014-12-03
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.251 Å)
Cite:Switching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263Trp
Biotechnol.Bioeng., 111, 2014
4P62
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BU of 4p62 by Molmil
Directed evolution of a B3 metallo-beta-lactamase AIM-1
Descriptor: 1,2-ETHANEDIOL, Metallo-beta-lactamase AIM-1, ZINC ION
Authors:Hou, C.-F.D, Collyer, C, Ollis, D.L.
Deposit date:2014-03-21
Release date:2015-05-27
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Directed evolution of a B3 metallo-beta-lactamase AIM-1
To Be Published
4NQ5
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BU of 4nq5 by Molmil
Bacillus cereus Zn-dependent metallo-beta-lactamase at pH 7 complexed with compound CS319
Descriptor: (3R,5R,7aS)-5-(sulfanylmethyl)tetrahydro[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid, Beta-lactamase 2, POTASSIUM ION, ...
Authors:Gonzalez, J.M, Gonzalez, M.M, Vila, A.J.
Deposit date:2013-11-23
Release date:2014-11-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Inhibition of metallo-lactamases with bicyclic compounds
TO BE PUBLISHED
4NQ2
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BU of 4nq2 by Molmil
Structure of Zn(II)-bound metallo-beta-lactamse VIM-2 from Pseudomonas aeruginosa
Descriptor: ACETATE ION, Beta-lactamase class B VIM-2, ZINC ION
Authors:Aitha, M, Nix, J.C, Crowder, M.W, Page, R.C.
Deposit date:2013-11-23
Release date:2014-11-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Biochemical, Mechanistic, and Spectroscopic Characterization of Metallo-beta-lactamase VIM-2.
Biochemistry, 53, 2014
2WRS
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BU of 2wrs by Molmil
Crystal Structure of the Mono-Zinc Metallo-beta-lactamase VIM-4 from Pseudomonas aeruginosa
Descriptor: BETA-LACTAMASE VIM-4, CITRATE ANION, CITRIC ACID, ...
Authors:Lassaux, P, Hamel, M, Gulea, M, Delbruck, H, Traore, D.A.K, Mercuri, P.S, Horsfall, L, Dehareng, D, Gaumont, A.-C, Frere, J.-M, Ferrer, J.-L, Hoffmann, K, Galleni, M, Bebrone, C.
Deposit date:2009-09-02
Release date:2010-06-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Mercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-Beta-Lactamases.
J.Med.Chem., 53, 2010
4XUK
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BU of 4xuk by Molmil
Crystal structure of hydrolase AbOPH in beta lactamase superfamily
Descriptor: Putative hydrolase, ZINC ION
Authors:Chen, J, Xu, J.H, Zhou, J.H.
Deposit date:2015-01-26
Release date:2015-10-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Marked enhancement of Acinetobacter sp. organophosphorus hydrolase activity by a single residue substitution Ile211Ala
Bioresour Bioprocess, 2015
3ESH
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BU of 3esh by Molmil
Crystal structure of a probable metal-dependent hydrolase from Staphylococcus aureus. Northeast Structural Genomics target ZR314
Descriptor: Protein similar to metal-dependent hydrolase
Authors:Seetharaman, J, Chen, Y, Wang, H, Janjua, H, Foote, E.L, Xiao, R, Nair, R, Everett, J.K, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-10-06
Release date:2008-10-28
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a probable metal-dependent hydrolase from Staphylococcus aureus. Northeast Structural Genomics target ZR314
To be Published
2UYX
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BU of 2uyx by Molmil
metallo-beta-lactamase (1BC2) single point mutant D120S
Descriptor: BETA-LACTAMASE II, GLYCEROL, ZINC ION
Authors:Larrull, L.I, Fabiane, S.M, Kowalski, J.M, Bennett, B, Sutton, B.J, Vila, A.J.
Deposit date:2007-04-20
Release date:2007-05-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Asp-120 locates Zn2 for optimal metallo-beta-lactamase activity.
J. Biol. Chem., 282, 2007
2VW8
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BU of 2vw8 by Molmil
Crystal Structure of Quinolone signal response protein pqsE from Pseudomonas aeruginosa
Descriptor: 1,2-ETHANEDIOL, CACODYLATE ION, FE (II) ION, ...
Authors:Carter, L.G, Johnson, K.A, Liu, H, Mcmahon, S.A, Oke, M, Naismith, J.H, White, M.F.
Deposit date:2008-06-17
Release date:2010-07-14
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The Scottish Structural Proteomics Facility: Targets, Methods and Outputs.
J.Struct.Funct.Genomics, 11, 2010
3F9O
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BU of 3f9o by Molmil
Crystal Structure of the Di-Zinc Carbapenemase CphA from Aeromonas Hydrophila
Descriptor: Beta-lactamase, CARBONATE ION, CHLORIDE ION, ...
Authors:Delbruck, H, Hoffmann, K.M.V.
Deposit date:2008-11-14
Release date:2009-09-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:The structure of the dizinc subclass B2 metallo-beta-lactamase CphA reveals that the second inhibitory zinc ion binds in the histidine site
Antimicrob.Agents Chemother., 53, 2009
1KO3
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BU of 1ko3 by Molmil
VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa with Cys221 reduced
Descriptor: ACETATE ION, CHLORIDE ION, HYDROXIDE ION, ...
Authors:Garcia-Saez, I, Docquier, J.-D, Rossolini, G.M, Dideberg, O.
Deposit date:2001-12-20
Release date:2003-09-02
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:The three-dimensional structure of VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa in its reduced and oxidised form
J.Mol.Biol., 375, 2008
3FAI
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BU of 3fai by Molmil
The Di Zinc Carbapenemase CphA N220G mutant
Descriptor: Beta-lactamase, CHLORIDE ION, GLYCEROL, ...
Authors:Delbruck, H, Hoffmann, K.M.V.
Deposit date:2008-11-17
Release date:2009-09-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structure of the dizinc subclass B2 metallo-beta-lactamase CphA reveals that the second inhibitory zinc ion binds in the histidine site
Antimicrob.Agents Chemother., 53, 2009
3DH8
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BU of 3dh8 by Molmil
Structure of Pseudomonas Quinolone Signal Response Protein PqsE
Descriptor: FE (III) ION, Uncharacterized protein PA1000, bis(4-nitrophenyl) hydrogen phosphate
Authors:Yu, S, Blankenfeldt, W.
Deposit date:2008-06-17
Release date:2009-06-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein.
Biochemistry, 48, 2009

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