4LE6

Crystal structure of the phosphotriesterase OPHC2 from Pseudomonas pseudoalcaligenes

Summary for 4LE6

Entry DOI	10.2210/pdb4le6/pdb
Descriptor	Organophosphorus hydrolase, GLYCEROL, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	alpha beta/beta alpha sandwich, metallo-hydrolase, phosphotriesterase, hydrolase
Biological source	Pseudomonas pseudoalcaligenes
Total number of polymer chains	5
Total formula weight	176587.98
Authors	Gotthard, G.,Hiblot, J.,Chabriere, E.,Elias, M. (deposition date: 2013-06-25, release date: 2013-11-13, Last modification date: 2024-11-27)
Primary citation	Gotthard, G.,Hiblot, J.,Gonzalez, D.,Elias, M.,Chabriere, E. Structural and Enzymatic Characterization of the Phosphotriesterase OPHC2 from Pseudomonas pseudoalcaligenes. Plos One, 8:e77995-e77995, 2013 Cited by PubMed Abstract: Organophosphates (OPs) are neurotoxic compounds for which current methods of elimination are unsatisfactory; thus bio-remediation is considered as a promising alternative. Here we provide the structural and enzymatic characterization of the recently identified enzyme isolated from Pseudomonas pseudoalcaligenes dubbed OPHC2. OPHC2 belongs to the metallo-β-lactamase superfamily and exhibits an unusual thermal resistance and some OP degrading abilities. PubMed: 24223749 DOI: 10.1371/journal.pone.0077995 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation