8R5U

VIM-2 metallo-beta-lactamase in complex with benzebisheterocycle compound 14

Summary for 8R5U

Entry DOI	10.2210/pdb8r5u/pdb
Descriptor	Beta-lactamase VIM-2, FORMIC ACID, ZINC ION, ... (5 entities in total)
Functional Keywords	metallo-beta-lactamase, inhibitor, antimicrobial protein
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	2
Total formula weight	52458.25
Authors	Hinchliffe, P.,Spencer, J. (deposition date: 2023-11-17, release date: 2024-04-10)
Primary citation	Villamil, V.,Rossi, M.A.,Mojica, M.F.,Hinchliffe, P.,Martinez, V.,Castillo, V.,Saiz, C.,Banchio, C.,Macias, M.A.,Spencer, J.,Bonomo, R.A.,Vila, A.,Moreno, D.M.,Mahler, G. Rational Design of Benzobisheterocycle Metallo-beta-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes. J.Med.Chem., 67:3795-3812, 2024 Cited by PubMed: 38373290 DOI: 10.1021/acs.jmedchem.3c02209 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.56 Å)

Structure validation