2AZE
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![BU of 2aze by Molmil](/molmil-images/mine/2aze) | Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer | Descriptor: | Retinoblastoma-associated protein, Transcription factor Dp-1, Transcription factor E2F1 | Authors: | Rubin, S.M, Gall, A.L, Zheng, N, Pavletich, N.P. | Deposit date: | 2005-09-10 | Release date: | 2006-01-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell(Cambridge,Mass.), 123, 2005
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5E84
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![BU of 5e84 by Molmil](/molmil-images/mine/5e84) | ATP-bound state of BiP | Descriptor: | 78 kDa glucose-regulated protein, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Liu, Q, Yang, J, Nune, M, Zong, Y, Zhou, L. | Deposit date: | 2015-10-13 | Release date: | 2016-01-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Close and Allosteric Opening of the Polypeptide-Binding Site in a Human Hsp70 Chaperone BiP. Structure, 23, 2015
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6LQG
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![BU of 6lqg by Molmil](/molmil-images/mine/6lqg) | Human gamma-secretase in complex with small molecule Avagacestat | Descriptor: | (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoranyl-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-tris(fluoranyl)pentanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, G, Zhou, R, Guo, X, Lei, J, Shi, Y. | Deposit date: | 2020-01-13 | Release date: | 2021-01-27 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184, 2021
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6LR4
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![BU of 6lr4 by Molmil](/molmil-images/mine/6lr4) | Molecular basis for inhibition of human gamma-secretase by small molecule | Descriptor: | (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, G, Zhou, R, Guo, X, Lei, J, Shi, Y. | Deposit date: | 2020-01-15 | Release date: | 2021-01-27 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184, 2021
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2BW2
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![BU of 2bw2 by Molmil](/molmil-images/mine/2bw2) | BofC from Bacillus subtilis | Descriptor: | BYPASS OF FORESPORE C | Authors: | Patterson, H.M, Brannigan, J.A, Cutting, S.M, Wilson, K.S, Wilkinson, A.J, Ab, E, Diercks, T, Folkers, G.E, de Jong, R.N, Truffault, V, Kaptein, R. | Deposit date: | 2005-07-08 | Release date: | 2005-09-15 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The structure of bypass of forespore C, an intercompartmental signaling factor during sporulation in Bacillus. J. Biol. Chem., 280, 2005
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7S1P
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![BU of 7s1p by Molmil](/molmil-images/mine/7s1p) | PRMT5/MEP50 crystal structure with sinefungin bound | Descriptor: | Methylosome protein 50, Protein arginine N-methyltransferase 5, SINEFUNGIN | Authors: | Gunn, R.J, Thomas, N.C, Lawson, J.D, Ivetac, A, Kulyk, S, Smith, C.R, Marx, M.A. | Deposit date: | 2021-09-02 | Release date: | 2022-03-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of MTAP -Deleted Cancers. J.Med.Chem., 65, 2022
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6MG1
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![BU of 6mg1 by Molmil](/molmil-images/mine/6mg1) | C-terminal bZIP domain of human C/EBPbeta with 16bp Methylated Oligonucleotide Containing Consensus Recognition Sequence-C2 Crystal Form | Descriptor: | 1,2-ETHANEDIOL, 16-bp methylated oligonucleotide, CCAAT/enhancer-binding protein beta, ... | Authors: | Horton, J.R, Cheng, X, Yang, J. | Deposit date: | 2018-09-12 | Release date: | 2018-12-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural basis for effects of CpA modifications on C/EBP beta binding of DNA. Nucleic Acids Res., 47, 2019
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6MG3
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![BU of 6mg3 by Molmil](/molmil-images/mine/6mg3) | V285A Mutant of the C-terminal bZIP domain of human C/EBPbeta with 16bp Methylated Oligonucleotide Containing Consensus Recognition Sequence | Descriptor: | 1,2-ETHANEDIOL, 16-bp methylated oligonucleotide, CCAAT/enhancer-binding protein beta | Authors: | Horton, J.R, Cheng, X, Yang, J. | Deposit date: | 2018-09-12 | Release date: | 2018-12-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural basis for effects of CpA modifications on C/EBP beta binding of DNA. Nucleic Acids Res., 47, 2019
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6MG2
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![BU of 6mg2 by Molmil](/molmil-images/mine/6mg2) | C-terminal bZIP domain of human C/EBPbeta with 16bp Methylated Oligonucleotide Containing Consensus Recognition Sequence-C2221 Crystal Form | Descriptor: | 1,2-ETHANEDIOL, 16-bp methylated oligonucleotide, CCAAT/enhancer-binding protein beta | Authors: | Horton, J.R, Cheng, X, Yang, J. | Deposit date: | 2018-09-12 | Release date: | 2018-12-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.928 Å) | Cite: | Structural basis for effects of CpA modifications on C/EBP beta binding of DNA. Nucleic Acids Res., 47, 2019
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5M35
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![BU of 5m35 by Molmil](/molmil-images/mine/5m35) | |
2BKA
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![BU of 2bka by Molmil](/molmil-images/mine/2bka) | CC3(TIP30)Crystal Structure | Descriptor: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | El Omari, K, Bird, L.E, Nichols, C.E, Ren, J, Stammers, D.K. | Deposit date: | 2005-02-14 | Release date: | 2005-02-21 | Last modified: | 2016-12-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structure of Cc3 (Tip30): Implications for its Role as a Tumor Suppressor J.Biol.Chem., 280, 2005
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1IMH
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![BU of 1imh by Molmil](/molmil-images/mine/1imh) | TonEBP/DNA COMPLEX | Descriptor: | 5'-D(*AP*AP*CP*TP*AP*TP*TP*TP*TP*TP*CP*CP*AP*GP*C)-3', 5'-D(*TP*TP*GP*CP*TP*GP*GP*AP*AP*AP*AP*AP*TP*AP*G)-3', NUCLEAR FACTOR OF ACTIVATED T CELLS 5 | Authors: | Stroud, J.C, Lopez-Rodriguez, C, Rao, A, Chen, L. | Deposit date: | 2001-05-10 | Release date: | 2002-02-01 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.86 Å) | Cite: | Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor. Nat.Struct.Biol., 9, 2002
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5C9Z
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![BU of 5c9z by Molmil](/molmil-images/mine/5c9z) | |
7SI5
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![BU of 7si5 by Molmil](/molmil-images/mine/7si5) | CRYSTAL STRUCTURE OF EED WITH MRTX-1919 | Descriptor: | (4R)-8-(1,3-dimethyl-1H-pyrazol-5-yl)-5-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}imidazo[1,2-c]pyrimidine-2-carbonitrile, 1,2-ETHANEDIOL, FORMIC ACID, ... | Authors: | Gunn, R.J, Burns, A.C, Lawson, J.D, Marx, M.A. | Deposit date: | 2021-10-12 | Release date: | 2022-11-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | CRYSTAL STRUCTURE OF EED WITH MRTX-1919 TO BE PUBLISHED
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7SI4
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![BU of 7si4 by Molmil](/molmil-images/mine/7si4) | CRYSTAL STRUCTURE OF EED WITH MRTX-2219 | Descriptor: | (4S)-8-{4-[(dimethylamino)methyl]-2-methylphenyl}-5-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}imidazo[1,2-c]pyrimidine-2-carbonitrile, FORMIC ACID, Polycomb protein EED | Authors: | Gunn, R.J, Burns, A.C, Lawson, J.D, Marx, M.A. | Deposit date: | 2021-10-12 | Release date: | 2022-11-09 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | CRYSTAL STRUCTURE OF EED WITH MRTX-2219 TO BE PUBLISHED
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5MPE
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![BU of 5mpe by Molmil](/molmil-images/mine/5mpe) | 26S proteasome in presence of ATP (s2) | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome regulatory subunit RPN1, 26S proteasome regulatory subunit RPN10, ... | Authors: | Wehmer, M, Rudack, T, Beck, F, Aufderheide, A, Pfeifer, G, Plitzko, J.M, Foerster, F, Schulten, K, Baumeister, W, Sakata, E. | Deposit date: | 2016-12-16 | Release date: | 2017-03-08 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structural insights into the functional cycle of the ATPase module of the 26S proteasome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6FFS
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![BU of 6ffs by Molmil](/molmil-images/mine/6ffs) | Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors | Descriptor: | 3C Protease, SULFATE ION, ~{N}-[(2~{S},5~{S},14~{S})-2-[(4-fluorophenyl)methyl]-5-(hydroxymethyl)-9-methyl-3,8,15-tris(oxidanylidene)-1,4,9-triazacyclopentadec-14-yl]-5-methyl-1,2-oxazole-3-carboxamide | Authors: | Wiesmann, C, Farady, C. | Deposit date: | 2018-01-09 | Release date: | 2018-02-21 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors. Bioorg. Med. Chem. Lett., 28, 2018
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3VDD
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![BU of 3vdd by Molmil](/molmil-images/mine/3vdd) | Structure of HRV2 capsid complexed with antiviral compound BTA798 | Descriptor: | 3-ethoxy-6-{2-[1-(6-methylpyridazin-3-yl)piperidin-4-yl]ethoxy}-1,2-benzoxazole, Protein VP1, Protein VP2, ... | Authors: | Morton, C.J, Feil, S.C, Parker, M.W. | Deposit date: | 2012-01-05 | Release date: | 2012-09-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus. ACS Med Chem Lett, 3, 2012
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1JFW
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![BU of 1jfw by Molmil](/molmil-images/mine/1jfw) | |
7O7B
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![BU of 7o7b by Molmil](/molmil-images/mine/7o7b) | |
7T3A
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![BU of 7t3a by Molmil](/molmil-images/mine/7t3a) | GATOR1-RAG-RAGULATOR - Inhibitory Complex | Descriptor: | GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ... | Authors: | Egri, S.B, Shen, K. | Deposit date: | 2021-12-07 | Release date: | 2022-04-06 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82, 2022
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7T3B
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![BU of 7t3b by Molmil](/molmil-images/mine/7t3b) | GATOR1-RAG-RAGULATOR - GAP Complex | Descriptor: | ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ... | Authors: | Egri, S.B, Shen, K. | Deposit date: | 2021-12-07 | Release date: | 2022-04-06 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82, 2022
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7T3C
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![BU of 7t3c by Molmil](/molmil-images/mine/7t3c) | GATOR1-RAG-RAGULATOR - Dual Complex | Descriptor: | ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ... | Authors: | Egri, S.B, Shen, K. | Deposit date: | 2021-12-07 | Release date: | 2022-04-06 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82, 2022
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2BUJ
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![BU of 2buj by Molmil](/molmil-images/mine/2buj) | Crystal structure of the human Serine-threonine Kinase 16 in complex with staurosporine | Descriptor: | CHLORIDE ION, SERINE/THREONINE-PROTEIN KINASE 16, STAUROSPORINE | Authors: | Debreczeni, J.E, Eswaran, J, Bullock, A, Filippakopoulos, P, Kavanagh, K, Amos, A, Fedorov, O, Sobott, F, Ball, L.J, von Delft, F, Arrowsmith, C, Sundstrom, M, Edwards, A, Knapp, S. | Deposit date: | 2005-06-13 | Release date: | 2005-07-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of the Human Serine-Threonine Kinase 16 in Complex with Staurosporine To be Published
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2C8I
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![BU of 2c8i by Molmil](/molmil-images/mine/2c8i) | Complex Of Echovirus Type 12 With Domains 1, 2, 3 and 4 Of Its Receptor Decay Accelerating Factor (Cd55) By Cryo Electron Microscopy At 16 A | Descriptor: | COMPLEMENT DECAY-ACCELERATING FACTOR, ECHOVIRUS 11 COAT PROTEIN VP1, ECHOVIRUS 11 COAT PROTEIN VP2, ... | Authors: | Pettigrew, D.M, Williams, D.T, Kerrigan, D, Evans, D.J, Lea, S.M, Bhella, D. | Deposit date: | 2005-12-05 | Release date: | 2006-01-17 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (14 Å) | Cite: | Structural and Functional Insights Into the Interaction of Echoviruses and Decay-Accelerating Factor. J.Biol.Chem., 281, 2006
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