6LQG

Human gamma-secretase in complex with small molecule Avagacestat

Summary for 6LQG

• Entry DOI: 10.2210/pdb6lqg/pdb
• EMDB information: 0944
• Descriptor: Nicastrin, CHOLESTEROL, Presenilin-1, ... (10 entities in total)
• Functional Keywords: small molecule, membrane protein, membrane protein-hydrolase complex, membrane protein/hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 184334.94

Authors

Yang, G.,Zhou, R.,Guo, X.,Lei, J.,Shi, Y. (deposition date: 2020-01-13, release date: 2021-01-27, Last modification date: 2021-02-03)

• Primary citation: Yang, G.,Zhou, R.,Guo, X.,Yan, C.,Lei, J.,Shi, Y.; Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.; Cell, 184:521-533.e14, 2021; PubMed: 33373587; DOI: 10.1016/j.cell.2020.11.049

Experimental method

ELECTRON MICROSCOPY (3.1 Å)