6LR4

Molecular basis for inhibition of human gamma-secretase by small molecule

Summary for 6LR4

• Entry DOI: 10.2210/pdb6lr4/pdb
• EMDB information: 0944 0957
• Descriptor: Nicastrin, CHOLESTEROL, Presenilin-1, ... (10 entities in total)
• Functional Keywords: inhibitor, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 184175.49

Authors

Yang, G.,Zhou, R.,Guo, X.,Lei, J.,Shi, Y. (deposition date: 2020-01-15, release date: 2021-01-27, Last modification date: 2021-02-03)

• Primary citation: Yang, G.,Zhou, R.,Guo, X.,Yan, C.,Lei, J.,Shi, Y.; Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.; Cell, 184:521-533.e14, 2021; PubMed: 33373587; DOI: 10.1016/j.cell.2020.11.049

Experimental method

ELECTRON MICROSCOPY (3 Å)