3VDD

Structure of HRV2 capsid complexed with antiviral compound BTA798

Summary for 3VDD

• Entry DOI: 10.2210/pdb3vdd/pdb
• Descriptor: Protein VP1, Protein VP2, Protein VP3, ... (6 entities in total)
• Functional Keywords: viral capsid, virus-drug complex, virus
• Biological source: Human rhinovirus 2 (HRV-2); More
• Cellular location: Capsid protein VP0: Virion (By similarity). Capsid protein VP4: Virion (By similarity). Capsid protein VP2: Virion (By similarity). Capsid protein VP3: Virion (By similarity). Capsid protein VP1: Virion (By similarity). Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3AB: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Viral protein genome-linked: Virion (By similarity). Protease 3C: Host cytoplasm (By similarity). Protein 3CD: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). RNA-directed RNA polymerase: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P04936 P04936 P04936 P04936
• Total number of polymer chains: 4
• Total formula weight: 95262.10

Authors

Morton, C.J.,Feil, S.C.,Parker, M.W. (deposition date: 2012-01-05, release date: 2012-09-12, Last modification date: 2023-09-13)

• Primary citation: Feil, S.C.,Hamilton, S.,Krippner, G.Y.,Lin, B.,Luttick, A.,McConnell, D.B.,Nearn, R.,Parker, M.W.,Ryan, J.,Stanislawski, P.C.,Tucker, S.P.,Watson, K.G.,Morton, C.J.; An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus.; ACS Med Chem Lett, 3:303-307, 2012; PubMed: 24900468; DOI: 10.1021/ml2002955

Experimental method

X-RAY DIFFRACTION (3.2 Å)