1KPC
| PKCI-1-APO+ZINC | Descriptor: | HUMAN PROTEIN KINASE C INTERACTING PROTEIN 1 (ZINC PROTEIN) | Authors: | Lima, C.D, Klein, M.G, Weinstein, I.B, Hendrickson, W.A. | Deposit date: | 1996-01-06 | Release date: | 1996-07-11 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Three-dimensional structure of human protein kinase C interacting protein 1, a member of the HIT family of proteins. Proc.Natl.Acad.Sci.USA, 93, 1996
|
|
7JYA
| Crystal structure of E3 ligase in complex with peptide | Descriptor: | ASN-ARG-ARG-ARG-ARG-TRP-ARG-GLU-ARG-GLN-ARG, Protein fem-1 homolog C, UNKNOWN ATOM OR ION | Authors: | Yan, X, Dong, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Min, J.R, Dong, C, Structural Genomics Consortium (SGC) | Deposit date: | 2020-08-30 | Release date: | 2020-10-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Molecular basis for ubiquitin ligase CRL2 FEM1C -mediated recognition of C-degron. Nat.Chem.Biol., 17, 2021
|
|
2PTD
| PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C MUTANT D198E | Descriptor: | PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C | Authors: | Heinz, D.W. | Deposit date: | 1997-07-16 | Release date: | 1998-01-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Probing the roles of active site residues in phosphatidylinositol-specific phospholipase C from Bacillus cereus by site-directed mutagenesis. Biochemistry, 36, 1997
|
|
1JO1
| N7-Guanine Adduct of 2,7-diaminomitosene with DNA | Descriptor: | 5'-D(*GP*TP*GP*(DAJ)GP*TP*AP*TP*AP*CP*CP*AP*C)-3', DECARBAMOYL-2,7-DIAMINOMITOSENE | Authors: | Subramaniam, G, Paz, M.M, Kumar, G.S, Das, A, Palom, Y, Clement, C.C, Patel, D.J, Tomasz, M. | Deposit date: | 2001-07-26 | Release date: | 2001-09-12 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity. Biochemistry, 40, 2001
|
|
3PH2
| |
4AEP
| |
2AX0
| Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x) | Descriptor: | 5R-(2E-METHYL-3-PHENYL-ALLYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE, Genome polyprotein, SULFATE ION | Authors: | Powers, J.P, Piper, D.E, Li, Y, Mayorga, V, Anzola, J, Chen, J.M, Jaen, J.C, Lee, G, Liu, J, Peterson, M.G, Tonn, G.R, Ye, Q, Walker, N.P, Wang, Z. | Deposit date: | 2005-09-02 | Release date: | 2006-01-24 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase. J.Med.Chem., 49, 2006
|
|
5TZD
| Structure of the WT S. venezulae BldD-(CTD-c-di-GMP)2 assembly intermediate | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein | Authors: | Schumacher, M. | Deposit date: | 2016-11-21 | Release date: | 2017-04-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.749 Å) | Cite: | The Streptomyces master regulator BldD binds c-di-GMP sequentially to create a functional BldD2-(c-di-GMP)4 complex. Nucleic Acids Res., 45, 2017
|
|
4OAY
| BldD CTD-c-di-GMP complex | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), DNA-binding protein | Authors: | Schumacher, M.A, Tschowri, N, Buttner, M, Brennan, R.G. | Deposit date: | 2014-01-06 | Release date: | 2014-11-19 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development. Cell(Cambridge,Mass.), 158, 2014
|
|
4OO9
| Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator mavoglurant | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Mavoglurant, Metabotropic glutamate receptor 5, ... | Authors: | Dore, A.S, Okrasa, K, Patel, J.C, Serrano-Vega, M, Bennett, K, Cooke, R.M, Errey, J.C, Jazayeri, A, Khan, S, Tehan, B, Weir, M, Wiggin, G.R, Marshall, F.H. | Deposit date: | 2014-01-31 | Release date: | 2014-07-02 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain. Nature, 511, 2014
|
|
7Y3B
| Crystal structure of TRIM7 bound to GN1 | Descriptor: | E3 ubiquitin-protein ligase TRIM7,TRIM7-GN1 | Authors: | Dong, C, Yan, X. | Deposit date: | 2022-06-10 | Release date: | 2022-08-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | C-terminal glutamine acts as a C-degron targeted by E3 ubiquitin ligase TRIM7. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
7Y3C
| Crystal structure of TRIM7 bound to RACO-1 | Descriptor: | E3 ubiquitin-protein ligase TRIM7,E3 ubiquitin-protein ligase TRIM7,TRIM7-RACO-1 | Authors: | Dong, C, Yan, X. | Deposit date: | 2022-06-10 | Release date: | 2022-08-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | C-terminal glutamine acts as a C-degron targeted by E3 ubiquitin ligase TRIM7. Proc.Natl.Acad.Sci.USA, 119, 2022
|
|
5WSQ
| Crystal structure of C-Hg-T pair containing DNA duplex | Descriptor: | 1,3-PROPANDIOL, DNA (5'-D(*GP*CP*CP*CP*GP*TP*GP*C)-3'), MERCURY (II) ION | Authors: | Gan, J.H, Liu, H.H. | Deposit date: | 2016-12-08 | Release date: | 2017-02-08 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex Nucleic Acids Res., 45, 2017
|
|
3KVS
| |
2JNF
| |
4R1V
| Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors | Descriptor: | 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile, GAMMA-BUTYROLACTONE, Hepatocyte growth factor receptor | Authors: | Blaukat, A, Bladt, F, Friese-Hamim, M, Knuehl, C, Fittschen, C, Graedler, U, Meyring, M, Dorsch, D, Stieber, F, Schadt, O. | Deposit date: | 2014-08-07 | Release date: | 2015-03-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
|
|
3CJ0
| |
2GIR
| Hepatitis C virus RNA-dependent RNA polymerase NS5B with NNI-1 inhibitor | Descriptor: | 3-{ISOPROPYL[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]AMINO}-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID, RNA-directed RNA polymerase | Authors: | Harris, S.F. | Deposit date: | 2006-03-29 | Release date: | 2007-04-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus. J.Virol., 80, 2006
|
|
1RJH
| Structure of the Calcium Free Form of the C-type Lectin-like Domain of Tetranectin | Descriptor: | Tetranectin | Authors: | Nielbo, S, Thomsen, J.K, Graversen, J.H, Etzerodt, M, Poulsen, F.M, Thoegersen, H.C. | Deposit date: | 2003-11-19 | Release date: | 2004-07-20 | Last modified: | 2024-10-16 | Method: | SOLUTION NMR | Cite: | Structure of the Plasminogen Kringle 4 Binding Calcium-Free Form of the C-Type Lectin-Like Domain of Tetranectin. Biochemistry, 43, 2004
|
|
3CJ3
| |
2KLO
| Structure of the Cdt1 C-terminal domain | Descriptor: | DNA replication factor Cdt1 | Authors: | Khayrutdinov, B.I, Bae, W.J, Yun, Y.M, Tsuyama, T, Kim, J.J, Hwang, E, Ryu, K.-S, Cheong, H.-K, Cheong, C, Karplus, P.A, Guntert, P, Tada, S, Jeon, Y.H, Cho, Y. | Deposit date: | 2009-07-06 | Release date: | 2009-10-13 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure of the Cdt1 C-terminal domain: Conservation of the winged helix fold in replication licensing factors Protein Sci., 18, 2009
|
|
4ATG
| TAF6 C-terminal domain from Antonospora locustae | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, TAF6 | Authors: | Romier, C. | Deposit date: | 2012-05-07 | Release date: | 2012-06-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | TFIID Taf6-Taf9 Complex Formation Involves the Heat Repeat-Containing C-Terminal Domain of Taf6 and is Modulated by Taf5 Protein. J.Biol.Chem., 287, 2012
|
|
2A4W
| Crystal Structure Of Mitomycin C-Binding Protein Complexed with Copper(II)-Bleomycin A2 | Descriptor: | BLEOMYCIN A2, COPPER (II) ION, Mitomycin-Binding Protein | Authors: | Danshiitsoodol, N, de Pinho, C.A, Matoba, Y, Kumagai, T, Sugiyama, M. | Deposit date: | 2005-06-30 | Release date: | 2006-07-18 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The Mitomycin C (MMC)-binding Protein from MMC-producing Microorganisms Protects from the Lethal Effect of Bleomycin: Crystallographic Analysis to Elucidate the Binding Mode of the Antibiotic to the Protein J.Mol.Biol., 360, 2006
|
|
1RFA
| NMR SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF C-RAF-1 | Descriptor: | RAF1 | Authors: | Emerson, S.D, Madison, V.S, Palermo, R.E, Waugh, D.S, Scheffler, J.E, Tsao, K.-L, Kiefer, S.E, Liu, S.P, Fry, D.C. | Deposit date: | 1995-04-26 | Release date: | 1996-06-20 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of the Ras-binding domain of c-Raf-1 and identification of its Ras interaction surface. Biochemistry, 34, 1995
|
|
4G6A
| |