Crystal Structure of Human Dipeptidyl Peptidase I (Cathepsin C): Exclusion Domain Added to an Endopeptidase Framework Creates the Machine for Activation of Granular Serine Proteases

Summary for 1K3B
Descriptordipeptydil-peptidase I exclusion domain, dipeptydil-peptidase I light chain, dipeptydil-peptidase I heavy chain, ... (7 entities in total)
Functional Keywordshydrolase
Biological sourceHomo sapiens (human)
Total number of polymer chains3
Total formula weight40120.33
Turk, D.,Janjic, V.,Stern, I.,Podobnik, M.,Lamba, D.,Dahl, S.W.,Lauritzen, C.,Pedersen, J.,Turk, V.,Turk, B. (deposition date: 2001-10-02, release date: 2002-04-02, Last modification date: 2020-07-29)
Primary citationDahl, S.W.,Janjic, V.,Lamba, D.,Lauritzen, C.,Pedersen, J.,Podobnik, M.,Stern, I.,Turk, B.,Turk, D.,Turk, V.
Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases.
EMBO J., 20:6570-6582, 2001
PubMed: 11726493
DOI: 110.1093/emboj/20.23.6570
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-09