5THO

Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with N,C-capped Dipeptide Inhibitor PKS2205

Summary for 5THO

• Entry DOI: 10.2210/pdb5tho/pdb
• Related PRD ID: PRD_002250
• Descriptor: Proteasome subunit alpha, Proteasome subunit beta, N,N-diethyl-N~2~-(3-phenylpropanoyl)-L-asparaginyl-O-methyl-N-[(naphthalen-1-yl)methyl]-L-serinamide, ... (4 entities in total)
• Functional Keywords: dipeptide inhibitor, proteasome, mycobacterium tuberculosis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra); More
• Total number of polymer chains: 28
• Total formula weight: 725296.92

Authors

Hsu, H.C.,Li, H. (deposition date: 2016-09-30, release date: 2017-01-11, Last modification date: 2023-10-04)

• Primary citation: Hsu, H.C.,Singh, P.K.,Fan, H.,Wang, R.,Sukenick, G.,Nathan, C.,Lin, G.,Li, H.; Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.; Biochemistry, 56:324-333, 2017; PubMed: 27976853; DOI: 10.1021/acs.biochem.6b01107

Experimental method

X-RAY DIFFRACTION (3.002 Å)