PDB: 672 resultsInfo pagesStatus searchChemie searchBIRD

---

2AIX	X-ray structure of the GLUR2 ligand-binding core (S1S2J) in complex with (s)-thio-atpa at 2.2 a resolution. Descriptor: (S)-2-AMINO-3-(3-HYDROXY-5-TERT-BUTYLISOTHIAZOL-4-YL) PROPRIONIC ACID, Glutamate receptor 2 Authors: Kastrup, J.S. Deposit date: 2005-08-01 Release date: 2005-08-09 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Distinct kinetics of ionotropic glutamate receptor 2 splice variants characterized by fast agonist application and crystallization of a receptor-ligand complex. To be Published
2F36	Crystal Structure of the GluR5 Ligand Binding Core Dimer with Glutamate At 2.1 Angstroms Resolution Descriptor: GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 1, GLUTAMIC ACID, ... Authors: Mayer, M.L. Deposit date: 2005-11-18 Release date: 2006-04-04 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists. J.Neurosci., 26, 2006
2F34	Crystal Structure of the GluR5 Ligand Binding Core Dimer with UBP310 At 1.74 Angstroms Resolution Descriptor: (S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHENE-3-YL-METHYL)-5-METHYLPYRIMIDINE-2,4-DIONE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... Authors: Mayer, M.L. Deposit date: 2005-11-18 Release date: 2006-04-04 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists. J.Neurosci., 26, 2006
2F35	Crystal Structure of the GluR5 Ligand Binding Core with UBP302 At 1.87 Angstroms Resolution Descriptor: (S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... Authors: Mayer, M.L. Deposit date: 2005-11-18 Release date: 2006-04-04 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists. J.Neurosci., 26, 2006
8C2H	Transmembrane domain of active state homomeric GluA1 AMPA receptor in tandem with TARP gamma 3 Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ... Authors: Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. Deposit date: 2022-12-22 Release date: 2023-08-30 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (2.64 Å) Cite: Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8C1P	Active state homomeric GluA1 AMPA receptor in complex with TARP gamma 3 Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CYCLOTHIAZIDE, ... Authors: Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. Deposit date: 2022-12-21 Release date: 2023-08-30 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8C1S	Transmembrane domain of resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma 2 Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 2, ... Authors: Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. Deposit date: 2022-12-21 Release date: 2023-08-30 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8C2I	Transmembrane domain of resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3 Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ... Authors: Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. Deposit date: 2022-12-22 Release date: 2023-08-30 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8C1R	Resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma-2 Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 2, ... Authors: Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. Deposit date: 2022-12-21 Release date: 2023-08-30 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
8C1Q	Resting state homomeric GluA1 AMPA receptor in complex with TARP gamma 3 Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Glutamate receptor 1 flip isoform, ... Authors: Zhang, D, Ivica, J, Krieger, J.M, Ho, H, Yamashita, K, Cais, O, Greger, I. Deposit date: 2022-12-21 Release date: 2023-08-30 Last modified: 2023-10-11 Method: ELECTRON MICROSCOPY (2.82 Å) Cite: Structural mobility tunes signalling of the GluA1 AMPA glutamate receptor. Nature, 621, 2023
4BDL	Crystal structure of the GluK2 K531A LBD dimer in complex with glutamate Descriptor: GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2, GLUTAMIC ACID, ... Authors: Nayeem, N, Mayans, O, Green, T. Deposit date: 2012-10-05 Release date: 2013-04-10 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements. Open Biol., 3, 2013
4BDO	Crystal structure of the GluK2 K531A-T779G LBD dimer in complex with kainate Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2, ... Authors: Nayeem, N, Mayans, O, Green, T. Deposit date: 2012-10-05 Release date: 2013-04-10 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements. Open Biol., 3, 2013
4BDR	Crystal structure of the GluK2 R775A LBD dimer in complex with kainate Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... Authors: Nayeem, N, Mayans, O, Green, T. Deposit date: 2012-10-05 Release date: 2013-04-10 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements. Open Biol., 3, 2013
4BDM	Crystal structure of the GluK2 K531A LBD dimer in complex with kainate Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2 Authors: Nayeem, N, Mayans, O, Green, T. Deposit date: 2012-10-05 Release date: 2013-04-10 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements. Open Biol., 3, 2013
4BDQ	Crystal structure of the GluK2 R775A LBD dimer in complex with glutamate Descriptor: GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2, GLUTAMIC ACID, ... Authors: Nayeem, N, Mayans, O, Green, T. Deposit date: 2012-10-05 Release date: 2013-04-10 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements. Open Biol., 3, 2013
4BDN	Crystal structure of the GluK2 K531A-T779G LBD dimer in complex with glutamate Descriptor: GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2, GLUTAMIC ACID, ... Authors: Nayeem, N, Mayans, O, Green, T. Deposit date: 2012-10-05 Release date: 2013-04-10 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements. Open Biol., 3, 2013
6OVE	Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, 4-propylphenyl-ACEPC Descriptor: (3R,5S)-5-[(2R)-2-amino-2-carboxyethyl]-1-(4-propylphenyl)pyrazolidine-3-carboxylic acid, GLYCINE, Glutamate receptor ionotropic, ... Authors: Syrenne, J.T, Mou, T.C, Tamborini, L, Pinto, A, Sprang, S.R, Hansen, K.B. Deposit date: 2019-05-07 Release date: 2020-05-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of GluN1/GluN2A NMDA receptor agonist binding domains with glycine and antagonist, 3-ethylphenyl-ACEPC To Be Published
6SBT	Structure of GluK1 ligand-binding domain (S1S2) in complex with N-(7-(1H-imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl benzamide at 2.3 A resolution Descriptor: CHLORIDE ION, GLYCEROL, Glutamate receptor ionotropic, ... Authors: Moellerud, S, Frydenvang, K, Kastrup, J.S. Deposit date: 2019-07-22 Release date: 2019-10-30 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.3 Å) Cite: N-(7-(1H-Imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide, a New Kainate Receptor Selective Antagonist and Analgesic: Synthesis, X-ray Crystallography, Structure-Affinity Relationships, and in Vitro and in Vivo Pharmacology. Acs Chem Neurosci, 10, 2019
6PEQ	GluA2 in complex with its auxiliary subunit CNIH3 - map LBD-TMD-C3 - with antagonist ZK200775 -without NTD Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, Glutamate receptor 2, ... Authors: Nakagawa, T. Deposit date: 2019-06-20 Release date: 2019-12-04 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (2.97 Å) Cite: Structures of the AMPA receptor in complex with its auxiliary subunit cornichon. Science, 366, 2019
1FTJ	CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH GLUTAMATE AT 1.9 RESOLUTION Descriptor: GLUTAMATE RECEPTOR SUBUNIT 2, GLUTAMIC ACID, ZINC ION Authors: Armstrong, N, Gouaux, E. Deposit date: 2000-09-12 Release date: 2000-11-01 Last modified: 2018-01-31 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron, 28, 2000
4X48	Crystal structure of GluR2 ligand-binding core Descriptor: GLUTAMIC ACID, Glutamate receptor 2, N-{(3S,4S)-4-[4-(5-cyanothiophen-2-yl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide, ... Authors: Pandit, J. Deposit date: 2014-12-02 Release date: 2015-05-06 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.89 Å) Cite: The Discovery and Characterization of the alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N-{(3S,4S)-4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242). J.Med.Chem., 58, 2015
1FTK	CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2I) IN COMPLEX WITH KAINATE AT 1.6 A RESOLUTION Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLUTAMATE RECEPTOR SUBUNIT 2 Authors: Gouaux, E, Armstrong, N. Deposit date: 2000-09-12 Release date: 2000-11-01 Last modified: 2017-08-02 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron, 28, 2000
1FTM	CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH AMPA AT 1.7 RESOLUTION Descriptor: (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID, GLUTAMATE RECEPTOR SUBUNIT 2, ZINC ION Authors: Gouaux, E, Armstrong, N. Deposit date: 2000-09-12 Release date: 2000-11-01 Last modified: 2017-08-02 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron, 28, 2000
1FW0	CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH KAINATE AT 2.0 A RESOLUTION Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLUTAMATE RECEPTOR SUBUNIT 2 Authors: Armstrong, N, Gouaux, E. Deposit date: 2000-09-20 Release date: 2000-11-15 Last modified: 2017-08-02 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron, 28, 2000
1FTO	CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN THE APO STATE AT 2.0 A RESOLUTION Descriptor: GLUTAMATE RECEPTOR SUBUNIT 2 Authors: Armstrong, N, Gouaux, E. Deposit date: 2000-09-12 Release date: 2000-11-01 Last modified: 2017-08-02 Method: X-RAY DIFFRACTION (2 Å) Cite: Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron, 28, 2000

<12345678910111213141516>