6F29
Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-1-[2-Amino-2-carboxyethyl]-5,7-dihydrothieno[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 2.6A
Summary for 6F29
Entry DOI | 10.2210/pdb6f29/pdb |
Descriptor | Glutamate receptor ionotropic, kainate 3,Glutamate receptor ionotropic, kainate 3, (2~{S})-2-azanyl-3-[2,4-bis(oxidanylidene)-5,7-dihydrothieno[3,4-d]pyrimidin-1-yl]propanoic acid, POTASSIUM ION, ... (5 entities in total) |
Functional Keywords | ionotropic glutamate receptor, gluk3, ligand binding domain, membrane protein., membrane protein |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P42264 |
Total number of polymer chains | 1 |
Total formula weight | 29534.27 |
Authors | Venskutonyte, R.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2017-11-23, release date: 2018-02-28, Last modification date: 2024-01-17) |
Primary citation | Brogi, S.,Brindisi, M.,Butini, S.,Kshirsagar, G.U.,Maramai, S.,Chemi, G.,Gemma, S.,Campiani, G.,Novellino, E.,Fiorenzani, P.,Pinassi, J.,Aloisi, A.M.,Gynther, M.,Venskutonyte, R.,Han, L.,Frydenvang, K.,Kastrup, J.S.,Pickering, D.S. ( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation. J. Med. Chem., 61:2124-2130, 2018 Cited by PubMed: 29451794DOI: 10.1021/acs.jmedchem.8b00099 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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