6F29

Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-1-[2-Amino-2-carboxyethyl]-5,7-dihydrothieno[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 2.6A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue CGW A 301

Chain	Residue
A	TYR63
A	MET190
A	GLU191
A	THR194
A	TYR217
A	PRO90
A	LEU91
A	THR92
A	ARG97
A	GLY142
A	ALA143
A	THR144
A	ASN174

---

site_id	AC2
Number of Residues	2
Details	binding site for residue K A 302

Chain	Residue
A	SER24
A	ARG26

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site_id	AC3
Number of Residues	6
Details	binding site for residue K A 303

Chain	Residue
A	ASN5
A	ASN5
A	SER52
A	SER52
A	HOH406
A	HOH406

---

site_id	AC4
Number of Residues	2
Details	binding site for residue CL A 304

Chain	Residue
A	ARG33
A	LEU57

---

site_id	AC5
Number of Residues	2
Details	binding site for residue CL A 305

Chain	Residue
A	ASN31
A	ILE48

---

site_id	AC6
Number of Residues	4
Details	binding site for residue CL A 306

Chain	Residue
A	GLN239
A	ASP242
A	LEU244
A	HIS245

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:21907808

Chain	Residue	Details
A	THR92
A	ARG97
A	GLU191

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	GLY142

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN5
A	ASN204

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