5ZG1

Crystal structure of the GluA2o LBD in complex with glutamate and Compound-2

Summary for 5ZG1

Entry DOI	10.2210/pdb5zg1/pdb
Descriptor	Glutamate receptor 2, GLUTAMIC ACID, 9-(4-~{tert}-butylphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide, ... (6 entities in total)
Functional Keywords	ampa receptor ligand-binding domain, allosteric modulation complex, membrane protein, transport protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	60223.15
Authors	Sogabe, S.,Igaki, S.,Hirokawa, A.,Zama, Y.,Lane, W.,Snell, G. (deposition date: 2018-03-07, release date: 2019-01-16, Last modification date: 2023-11-22)
Primary citation	Kunugi, A.,Tanaka, M.,Suzuki, A.,Tajima, Y.,Suzuki, N.,Suzuki, M.,Nakamura, S.,Kuno, H.,Yokota, A.,Sogabe, S.,Kosugi, Y.,Awasaki, Y.,Kaku, T.,Kimura, H. TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window. Neuropsychopharmacology, 44:961-970, 2019 Cited by PubMed: 30209408 DOI: 10.1038/s41386-018-0213-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.32 Å)

Structure validation