5YBF

Crystal structure of the GluA2o LBD in complex with glutamate and HBT1

Summary for 5YBF

Entry DOI	10.2210/pdb5ybf/pdb
Descriptor	Glutamate receptor 2,Glutamate receptor 2, GLUTAMIC ACID, 2-[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanoylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, ... (6 entities in total)
Functional Keywords	ampa receptor ligand-binding domain, allosteric modulation complex, membrane protein, transport protein
Biological source	Homo sapiens (Human) More
Cellular location	Cell membrane ; Multi-pass membrane protein : P42262
Total number of polymer chains	6
Total formula weight	178841.11
Authors	Sogabe, S.,Igaki, S.,Hirokawa, A.,Zama, Y.,Lane, W.,Snell, G. (deposition date: 2017-09-04, release date: 2018-01-17, Last modification date: 2023-11-22)
Primary citation	Kunugi, A.,Tajima, Y.,Kuno, H.,Sogabe, S.,Kimura, H. HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production. J. Pharmacol. Exp. Ther., 364:377-389, 2018 Cited by PubMed: 29298820 DOI: 10.1124/jpet.117.245050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation